云南高校图书馆联盟文献共享服务平台- APP/PS1

APP/PS1: 作品数：235被引量：712H指数：11; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：蒋林周春妮唐勇龙志敏贺桂琼更多>>; 相关机构：重庆医科大学北京中医药大学中国医科大学山西医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金北京市自然科学基金中央高校基本科研业务费专项资金中国博士后科学基金更多>>

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease: 《Neural Regeneration Research》2025年第10期2982-2997,共16页Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min Yi Weijun Peng; financially supported by the National Natural Science Foundation of China,No.823 74552 (to WP);the Science and Technology Innovation Program of Hunan Province,No.2022RC1220 (to WP);the Natural Science Foundation of Hunan Province of China,Nos.2020JJ4803 (to WP),2022JJ40723 (to MY);the Scientific Research Launch Project for New Employees of the Second Xiangya Hospital of Central South University (to MY); Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota.The aim of this study was to investigate systemic changes that occur in Alzhei...; 关键词：Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

Treadmill exercise in combination with acousto-optic and olfactory stimulation improves cognitive function in APP/PS1 mice through the brain-derived neurotrophic factor-and Cygb-associated signaling pathways被引量：1: 《Neural Regeneration Research》2025年第9期2706-2726,共21页Biao Xiao Chaoyang Chu Zhicheng Lin Tianyuan Fang Yuyu Zhou Chuxia Zhang Jianghui Shan Shiyu Chen Liping Li; supported by the National Natural Science Foundation of China,No.82001155(to LL);the Natural Science Foundation of Zhejiang Province,No.LY23H090004(to LL);the Natural Science Foundation of Ningbo,No.2023J068(to LL);the Fundamental Research Funds for the Provincial Universities of Zhejiang Province,No.SJLY2023008(to LL);the College Students'Scientific and Technological Innovation Project(Xin Miao Talent Plan)of Zhejiang Province,No.2022R405A045(to CC);the Student Research;Innovation Program(SRIP)of Ningbo University,Nos.20235RIP1919(to CZ),2023SRIP1938(to YZ);the K.C.Wong Magna Fund in Ningbo University。; A reduction in adult neurogenesis is associated with behavioral abnormalities in patients with Alzheimer's disease.Consequently,enhancing adult neurogenesis represents a promising therapeutic approach for mitigating d...; 关键词：acousto-optic stimulation adult neurogenesis Alzheimer's disease amyloid precursor protein/presenilin 1 mice amyloid-beta deposition brain cell apoptosis cognitive impairment depression-like behavior involuntary treadmill exercise olfactory stimulation serum metabolites

灵芝醇提物对APP/PS1小鼠肠道菌群组成及多样性的影响: 《吉林医学》2025年第3期513-517,共5页傅伟淇邹师琪谭锻玲杨欣; 广州市卫生健康委员会中医药与中西医结合项目[项目编号:20212A011027];2023年度高水平大学“一流本科专业建设经费”资助项目[项目编号:2022JXA008];广州市科技局市校(院)企联合资助项目[项目编号:2024A03J0072]。; 目的:采用高通量测序研究灵芝醇提物对APP/PS1小鼠肠道菌群多样性及组成的影响。方法:APP/PS1小鼠随机分为模型组、灵芝组,每组10只,C57BL/6J小鼠为对照组(n=10),模型组和对照组用灵芝组等体积蒸馏水处理持续6个月,行为学评价后采集各...; 关键词：灵芝醇提物肠道菌群高通量测序

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice: 《Neural Regeneration Research》2025年第2期533-547,共15页Yanli Zhang Tian Li Jie Miao Zhina Zhang Mingxuan Yang Zhuoran Wang Bo Yang Jiawei Zhang Haiting Li Qiang Su Junhong Guo; supported by STI2030-Major Projects,No.2021ZD 0201801(to JG);Shanxi Province Basic Research Program,No.20210302123429(to QS).; In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of A...; 关键词：Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice: 《Neural Regeneration Research》2025年第1期253-264,共12页Zhengwei Hu Jing Yang Shuo Zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo Tang Changhe Shi Yuming Xu; supported by the National Natural Science Foundation of China,Nos.91849115 and U1904207(to YX),81974211 and 82171247(to CS);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences,No.2020-PT310-01(to YX).; The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control system.In this study,we aimed...; 关键词：adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

ERβ/JNK通路介导的杜仲提取物对APP/PS1双转基因小鼠学习记忆能力的影响被引量：1: 《中国中药杂志》2025年第2期285-292,共8页李月张莉莉赵灿赵红梅王堰付金蕾张杰张宁徐红丹; 国家自然科学基金面上项目(82174007,81673581);中央支持地方高校改革发展资金人才培养项目;无锡市卫生健康“三名”战略人才项目——中青年医疗卫生拔尖人才培养计划项目(BJ2023094);2022江苏高校“青蓝工程”优秀青年骨干教师培养项目。; 研究杜仲提取物对APP/PS1双转基因小鼠空间学习障碍的改善作用及探讨其与雌激素受体β(ERβ)/c-Jun氨基末端激酶(JNK)信号通路的关系。将60只3月龄雄性APP/PS1小鼠随机分为模型组、抗脑衰胶囊组(0.585 g·kg^(-1))、盐酸多奈哌齐组(0.65...; 关键词：杜仲提取物阿尔茨海默病 APP/PS1 ERΒ JNK

Effect of hUC-MSCs on the NLRP3/Caspase-1 Pathway in APP/PS1 Mice: 《Medicinal Plant》2024年第6期75-78,共4页Junjie CAI Fuhong LI Tianyu WANG Zhuorui HE Kaiyue LI Yufan ZANG Liqun REN; Supported by Major Project of Fundamental Research Funds for the Central Universities of Chengde Medical University(KY202217);Construction of Chengde Biomedical Industry Research Institute(202205B086).; [Objectives] To investigate the effect of human umbilical cord mesenchymal stem cells (hUC-MSCs) on the NOD-like receptor protein 3 (NLRP3)/cysteinyl aspartate specific proteinase (Caspase-1) pathway within the cerebr...; 关键词：Alzheimer s disease(AD) Human umbilical cord mesenchymal stem cells(hUC-MSCs) APP/PS1 mice NLRP3 inflammasome

阿尔茨海默症模型APP/PS1小鼠早期视皮层神经元活性变化: 《现代生物医学进展》2024年第21期4001-4006,共6页谢先屿蓝志达赵乐文王兆龙方伟群; 国家自然科学基金项目(32271023)。; 目的:探究2月龄阿尔茨海默症模型小鼠(APP/PS1)初级视皮层(primary visual cortex,V1)神经元在不同视觉刺激模式下的活性变化,解析APP/PS1小鼠早期V1的功能改变。方法:通过免疫荧光染色分析2月龄APP/PS1小鼠初级视皮层内Aβ表达情况,并...; 关键词：视皮层神经元活性 APP/PS1 阿尔茨海默症

Electroacupuncture Alleviates Memory Deficits in APP/PS1 Mice by Targeting Serotonergic Neurons in Dorsal Raphe Nucleus: 《Current Medical Science》2024年第5期987-1000,共14页Chao-chao YU Xiao-fei WANG Jia WANG Chu LI Juan XIAO Xue-song WANG Rui HAN Shu-qin WANG Yuan-fang LIN Li-hong KONG Yan-jun DU; supported by grants from the Shenzhen Science and Technology Program(No.2021-22154);National Natural Science Foundation of China(No.82205271,No.82374564,and No.82074566);Wuhan Medical Research Project(No.WZ21Q09);Key Chinese Medicine Project of Hubei Provincial Natural Science Foundation(No.2023AFD112).; Objective Alzheimer’s disease(AD)has become a significant global concern,but effective drugs able to slow down AD progression is still lacked.Electroacupuncture(EA)has been demonstrated to ameliorate cognitive impair...; 关键词：Alzheimer’s disease ELECTROACUPUNCTURE dorsal raphe nucleus HIPPOCAMPUS serotonergic neurons glutamatergic neurons 5-HT1B cognitive impairment chemogenetic manipulation synaptic plasticity

Electroacupuncture activates AMPKα1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer’s disease by regulating hippocampal mitochondrial dynamics: 《Journal of Integrative Medicine》2024年第5期588-599,共12页Wei-wei Jia Hua-wei Lin Min-guang Yang Ya-ling Dai Yan-yi Ding Wen-shan Xu Si-nuo Wang Ya-jun Cao Sheng-xiang Liang Zhi-fu Wang Cong Chen Wei-lin Liu; supported by the Fujian Provincial Outstanding Natural Science Foundation(No.2021J06028);the key project at the central government level:the ability establishment of sustainable use for valuable Chinese Medicine Resources(No.2060302).; Objective Studies have shown that electroacupuncture(EA)can alleviate cognitive impairments from Alzheimer’s disease(AD)by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK),but the s...; 关键词：Adenosine monophosphate-activated protein kinase Alzheimer’s disease Cognitive impairment ELECTROACUPUNCTURE HIPPOCAMPUS Mitochondrial dynamics

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

APP/PS1

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

APP/PS1

检索结果分析

下载全文

用户登录

高级检索检索式检索