Molecular Epidemiology and Clinical Characteristics of Hand, Foot and Mouth Disease in North Sichuan Region, China, 2018-2023: A Descriptive Study  

作　　者：Zhe Xu Zheng Zhao Linming Fan Manyu Liang Jinglu Chen Jia Zeng Ping Shi Xi’en Gu Zhengdong Li Zhe Xu;Zheng Zhao;Linming Fan;Manyu Liang;Jinglu Chen;Jia Zeng;Ping Shi;Xi’en Gu;Zhengdong Li(Department of Pediatrics, Guangyuan Central Hospital, Guangyuan, China;Department of Clinical Laboratory, Guangyuan Central Hospital, Guangyuan, China;Department of Dermatology, Guangyuan Central Hospital, Guangyuan, China;Precision Medical Centre, Guangyuan Central Hospital, North Sichuan Regional Medical Centre, Guangyuan, China;Department of Pulmonary and Critical Care Medicine, Guangyuan Central Hospital, Guangyuan, China)

机构地区：[1]Department of Pediatrics, Guangyuan Central Hospital, Guangyuan, China [2]Department of Clinical Laboratory, Guangyuan Central Hospital, Guangyuan, China [3]Department of Dermatology, Guangyuan Central Hospital, Guangyuan, China [4]Precision Medical Centre, Guangyuan Central Hospital, North Sichuan Regional Medical Centre, Guangyuan, China [5]Department of Pulmonary and Critical Care Medicine, Guangyuan Central Hospital, Guangyuan, China

出　　处：《Advances in Microbiology》2024年第6期317-332,共16页微生物学（英文）

摘　　要：Background: Hand, foot and mouth disease (HFMD) remains an important public health problem in China. Many studies on the epidemiological characteristics of HFMD have been reported, but studies in North Sichuan region have been neglected. Methods: HFMD-related enterovirus infected cases were clinically confirmed and underwent real-time RT-PCR (rRT-PCR) from May 2018 to October 2023 in Guangyuan Central Hospital. Results: During 2018-2023, other EV (437 cases, 81.08%) was the most predominant serotype followed by CV-A16 (94 cases, 17.44%), EV-A71 (8 cases, 1.48%) was the least predominant serotype. Peak infections occurred in July and October. There were no significant differences in gender, age and serotypes. HFMD was concentrated in children under 47 months of age, with the highest incidence in children aged 12 - 23 months and the highest proportion of other EV infections in the whole age group. COVID-19 did not cause significant changes in gender, age and serotype. Overall, there was a significant increase in the proportion of children aged 12 - 23 months infected with CV-A16, and an increase in the proportion of children aged over 36 months infected with other EVs. Conclusions: The incidence of HFMD caused by EV-A71 has decreased significantly, and other EVs have become the main pathogens of HFMD in North Sichuan region in recent years. In the prevention and control of CV-A16, more attention should be paid to children aged 12 - 23 months and the dominant serotype should be closely monitored. Our study highlights the importance of developing of new diagnostic reagents and vaccines for the prevention and control of enterovirus infection. This study for the first time provides insights into district interventions to local conditions.Background: Hand, foot and mouth disease (HFMD) remains an important public health problem in China. Many studies on the epidemiological characteristics of HFMD have been reported, but studies in North Sichuan region have been neglected. Methods: HFMD-related enterovirus infected cases were clinically confirmed and underwent real-time RT-PCR (rRT-PCR) from May 2018 to October 2023 in Guangyuan Central Hospital. Results: During 2018-2023, other EV (437 cases, 81.08%) was the most predominant serotype followed by CV-A16 (94 cases, 17.44%), EV-A71 (8 cases, 1.48%) was the least predominant serotype. Peak infections occurred in July and October. There were no significant differences in gender, age and serotypes. HFMD was concentrated in children under 47 months of age, with the highest incidence in children aged 12 - 23 months and the highest proportion of other EV infections in the whole age group. COVID-19 did not cause significant changes in gender, age and serotype. Overall, there was a significant increase in the proportion of children aged 12 - 23 months infected with CV-A16, and an increase in the proportion of children aged over 36 months infected with other EVs. Conclusions: The incidence of HFMD caused by EV-A71 has decreased significantly, and other EVs have become the main pathogens of HFMD in North Sichuan region in recent years. In the prevention and control of CV-A16, more attention should be paid to children aged 12 - 23 months and the dominant serotype should be closely monitored. Our study highlights the importance of developing of new diagnostic reagents and vaccines for the prevention and control of enterovirus infection. This study for the first time provides insights into district interventions to local conditions.

关 键 词：ENTEROVIRUS HFMD EPIDEMIOLOGY Clinical Characteristics 

分 类 号：R72[医药卫生—儿科]