Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease  

作　　者：Angelo M. Scanu Diana M. Stafforini Celina Edelstein 

机构地区：[1]Department of Medicine, University of Chicago, Chicago, USA [2]Department of Medicine, University of Chicago, Chicago, USA Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, USA [3]Huntsman Cancer Institute, University of Utah, Salt Lake City, USA

出　　处：《American Journal of Molecular Biology》2012年第2期110-112,共3页美国分子生物学期刊（英文）

摘　　要：Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A2 for which cleavage specificity has been established when these modified lipids are in a free form.Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A2 for which cleavage specificity has been established when these modified lipids are in a free form.

关 键 词：PLASMINOGEN Apolipoprotein(a) Lipoprotein(a) OXIDIZED PHOSPHOLIPIDS OXIDIZED PHOSPHATIDYLCHOLINES 

分 类 号：R5[医药卫生—内科学]