Effect of SRD-P401 on the Discomfort of Neck and/or Shoulder Stiffness  

作　　者：Akira Iizuka Maasa Sonoda Ruka Goto Tokunori Matsui Chiaki Kudoh Katsumi Kido Yasuhiro Komatsu 

机构地区：[1]Center for Supporting Pharmaceutical Education, Daiich University of Pharmacy, Fukuoka, Japan [2]Clinical Pharmacy Education Center, Japan College of Pharmaceutical Science, Saitama, Japan [3]Sun R and D Institute for Natural Medicines Co., Inc., Tokyo, Japan [4]KUDOH CHIAKI Clinic for Neurosurgery & Neurology, Tokyo Brain & Spinal Cord Research Institute, Tokyo, Japan [5]Department of Pharmacognosy, Daiich University of Pharmacy, Fukuoka, Japan

出　　处：《American Journal of Plant Sciences》2017年第5期1065-1076,共12页美国植物学期刊（英文）

摘　　要：SRD-P401 is a newly developed healthy food supplement which has an anti-inflammatory and analgesic effect. In this report, the effects of SRD-P401 on neck and shoulder stiffness were assessed by an inquiry method in the public field. The stiffness symptoms of all participants were improved after taking SRD-P401. The symptoms of the participants who took 3 g/day and/or 9 g/day of SRD-P401 improved in a week after taking it. Unpleasant adverse effects in stomach and alimentally organs were not found during the test period. SRD-P401 showed the anti-nociceptive effect on the acetic-acid-induces abdominal writhing in rats. The potency was equivalent to aspirin. Moreover, to investigate the ability of the anti-inflammatory effects of SRD-P401, we exerted by inhibiting the Cyclooxygenase (COX) enzyme activity. SRD-P401 and its constituents inhibit the COX activity. The results of this field test indicated SRD-P401 would be a beneficial and useful healthy food supplement for a person with stiffness in neck and/or shoulder.SRD-P401 is a newly developed healthy food supplement which has an anti-inflammatory and analgesic effect. In this report, the effects of SRD-P401 on neck and shoulder stiffness were assessed by an inquiry method in the public field. The stiffness symptoms of all participants were improved after taking SRD-P401. The symptoms of the participants who took 3 g/day and/or 9 g/day of SRD-P401 improved in a week after taking it. Unpleasant adverse effects in stomach and alimentally organs were not found during the test period. SRD-P401 showed the anti-nociceptive effect on the acetic-acid-induces abdominal writhing in rats. The potency was equivalent to aspirin. Moreover, to investigate the ability of the anti-inflammatory effects of SRD-P401, we exerted by inhibiting the Cyclooxygenase (COX) enzyme activity. SRD-P401 and its constituents inhibit the COX activity. The results of this field test indicated SRD-P401 would be a beneficial and useful healthy food supplement for a person with stiffness in neck and/or shoulder.

关 键 词：SUPPLEMENT ANTI-INFLAMMATORY ANTI-NOCICEPTIVE SRD-P401 

分 类 号：R73[医药卫生—肿瘤]