<i>Spirulina platensis</i>Alleviates the Liver, Brain and Heart Oxidative Stress in Type 1 Diabetic Rats  

作　　者：Francisca Adilfa de Oliveira Garcia Violet G. Yuen Helioswilton Sales de Campos Eveline Turatti Glauce Socorro de Barros Viana Carlo José Freire Oliveira John H. McNeill 

机构地区：[1]Faculty of Pharmaceutical Sciences, The University of British Columbia (UBC), Vancouver, Canada [2]Departamento de Fisiologia, Faculdade de Medicina Estacio de Juazeiro do Norte (ESTACIO), Juazeiro do Norte, Brazil [3]Departamento de Microbiologia, Imunologia e parasitologia, Universidade Federal do Triangulo Mineiro (UFTM), Minas Gerais, Brazil [4]Faculdade de Odontologia, Universidade de Fortaleza (UNIFOR), Fortaleza, Brazil [5]Departamento de Farmacologia, Universidade Federal do Ceará(UFC), Fortaleza, Brazil

出　　处：《Food and Nutrition Sciences》2018年第6期735-750,共16页食品与营养科学（英文）

摘　　要：Spirulina platensis (SPI) is a microalga with a high content of functional compounds, such as phenolics, phycocyanins and polysaccharides that has been shown to have antioxidant, anti-inflammatory, hypoglycemic, neuro-protective and immunomodulatory effects. The objectives of the present work were to study the possible effects of SPI treatment on the glycemic-lipid profile, oxidative stress, lipid peroxidation and cardiac performance in diabetic rats. Diabetes was induced by streptozotocin (STZ) in male Wistar rats. In diabetic animals SPI, at a dose of 50 mg/kg/day, reduced lipid peroxidation, nitrite levels and lipids in plasma and tissues. SPI exhibited an effective improvement on +dP/dT and &minus;dP/dT in non-diabetic rats. This study showed that SPI significantly suppressed nitrite generation and lipoperoxidation in the hearts of diabetic animals, as well as an improvement in the cardiac function in control SPI-treated rats which is consistent with several studies that demonstrated the protective effect of antioxidants on oxidative stress-mediated injury caused by reactive oxygen species (ROS) produced in diabetic myocardial tissues.Spirulina platensis (SPI) is a microalga with a high content of functional compounds, such as phenolics, phycocyanins and polysaccharides that has been shown to have antioxidant, anti-inflammatory, hypoglycemic, neuro-protective and immunomodulatory effects. The objectives of the present work were to study the possible effects of SPI treatment on the glycemic-lipid profile, oxidative stress, lipid peroxidation and cardiac performance in diabetic rats. Diabetes was induced by streptozotocin (STZ) in male Wistar rats. In diabetic animals SPI, at a dose of 50 mg/kg/day, reduced lipid peroxidation, nitrite levels and lipids in plasma and tissues. SPI exhibited an effective improvement on +dP/dT and &minus;dP/dT in non-diabetic rats. This study showed that SPI significantly suppressed nitrite generation and lipoperoxidation in the hearts of diabetic animals, as well as an improvement in the cardiac function in control SPI-treated rats which is consistent with several studies that demonstrated the protective effect of antioxidants on oxidative stress-mediated injury caused by reactive oxygen species (ROS) produced in diabetic myocardial tissues.

关 键 词：SPIRULINA PLATENSIS LIPID Profile Cardiac Function OXIDATIVE Stress Diabetes 

分 类 号：R5[医药卫生—内科学]