Oral Sodium Hyaluronate Moisturizes Skin in Healthy Adults: An 8-Week, Randomized, Double-Blinded, Placebo-Controlled Study  

作　　者：Mariko Oe Wei Wang Keiko Kuriyama Yumi Takeda Mamoru Kimura Ryosuke Matsuoka Naoki Miura Jun Muto Mariko Oe;Wei Wang;Keiko Kuriyama;Yumi Takeda;Mamoru Kimura;Ryosuke Matsuoka;Naoki Miura;Jun Muto(R & D Division, Kewpie Corporation, Chofu-Shi, Japan;Miura Medical Clinic, Osaka, Japan;Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Japan)

机构地区：[1]R & D Division, Kewpie Corporation, Chofu-Shi, Japan [2]Miura Medical Clinic, Osaka, Japan [3]Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Japan

出　　处：《Food and Nutrition Sciences》2024年第11期1095-1105,共11页食品与营养科学（英文）

摘　　要：Objective: Few studies have evaluated the effect of oral sodium hyaluronate (SH) ingestion on the moisture content of the superficial stratum corneum. This study aimed to assess whether oral SH ingestion improves the moisture content of the upper layer of the stratum corneum, which is susceptible to changes in environmental humidity, using the Skicon 200EX. Design: Randomized, double-blind, placebo-controlled, parallel-group study. Participants: One hundred healthy Japanese men and women aged 20 - 64 years. Interventions: Oral ingestion of one 119-mg SH or dextrin (placebo) capsule once daily for 8 weeks. Evaluations: Measurement of water content in the superficial stratum corneum of the face and upper extremities using the Skicon 200EX. Results: Overall facial stratum corneum water content changes were significantly higher at 8 weeks in the SH group compared to the placebo group. Conclusions: In healthy Japanese adults, oral SH ingestion improved skin moisture by increasing the stratum corneum water content. Clinical Trial Registration: The study protocol was preregistered with the Clinical Trials Registry System (registration no. UMIN000053322, January 11, 2024).Objective: Few studies have evaluated the effect of oral sodium hyaluronate (SH) ingestion on the moisture content of the superficial stratum corneum. This study aimed to assess whether oral SH ingestion improves the moisture content of the upper layer of the stratum corneum, which is susceptible to changes in environmental humidity, using the Skicon 200EX. Design: Randomized, double-blind, placebo-controlled, parallel-group study. Participants: One hundred healthy Japanese men and women aged 20 - 64 years. Interventions: Oral ingestion of one 119-mg SH or dextrin (placebo) capsule once daily for 8 weeks. Evaluations: Measurement of water content in the superficial stratum corneum of the face and upper extremities using the Skicon 200EX. Results: Overall facial stratum corneum water content changes were significantly higher at 8 weeks in the SH group compared to the placebo group. Conclusions: In healthy Japanese adults, oral SH ingestion improved skin moisture by increasing the stratum corneum water content. Clinical Trial Registration: The study protocol was preregistered with the Clinical Trials Registry System (registration no. UMIN000053322, January 11, 2024).

关 键 词：Hyaluronic Acid HYALURONAN Ingestion Moisturize 

分 类 号：R78[医药卫生—口腔医学]