Changes in cerebral perfusion detected by dynamic susceptibility contrast magnetic resonance imaging: normal volunteers examined during normal breathing and hyperventilation  

作　　者：Ronnie Wirestam Christian Engvall Erik Ryding Stig Holtas Freddy Stahlberg Peter Reinstrup 

机构地区：[1]Department of Anaesthesiology & Intensive Care, Lund University Hospital, Lund, Sweden [2]Department of Clinical Neurophysiology, Lund University Hospital, Lund, Sweden [3]Department of Diagnostic Radiology, Lund University, Lund, Sweden [4]Department of Medical Radiation Physics, Lund University, Lund, Sweden [5]Department of Medical Radiation Physics, Lund University, Lund, Sweden

出　　处：《Journal of Biomedical Science and Engineering》2009年第4期210-215,共6页生物医学工程（英文）

摘　　要：Global cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) de-creased during hyperventilation in all volun-teers (average decrease 29%), and the corre-sponding global CBF estimates were 73±19ml/ (min100g) during normal breathing and 52± 7.9ml/(min100g) during hyperventilation (mean ±SD, n=8). Furthermore, the hypocapnic condi-tions induced by hyperventilation resulted in a prolongation of the global mean transit time (MTT) by on average 14%. The observed CBF estimates appeared to be systematically over-estimated, in accordance with previously pub-lished DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.Global cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) de-creased during hyperventilation in all volun-teers (average decrease 29%), and the corre-sponding global CBF estimates were 73±19ml/ (min100g) during normal breathing and 52± 7.9ml/(min100g) during hyperventilation (mean ±SD, n=8). Furthermore, the hypocapnic condi-tions induced by hyperventilation resulted in a prolongation of the global mean transit time (MTT) by on average 14%. The observed CBF estimates appeared to be systematically over-estimated, in accordance with previously pub-lished DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.

关 键 词：Magnetic Resonance Imaging PERFUSION CEREBRAL Blood Flow Mean TRANSIT Time Hypocapnia 

分 类 号：R73[医药卫生—肿瘤]