Predicting residue contacts for protein-protein interactions by integration of multiple information  

作　　者：Tu Kien T. Le Osamu Hirose Vu Anh Tran Thammakorn Saethang Lan Anh T. Nguyen Xuan Tho Dang Duc Luu Ngo Mamoru Kubo Yoichi Yamada Kenji Satou 

机构地区：[1]Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan [2]Institute of Science and Engineering, Kanazawa University, Kanazawa, Japan

出　　处：《Journal of Biomedical Science and Engineering》2014年第1期28-37,共10页生物医学工程（英文）

摘　　要：Detailed knowledge of interfacial region between interacting proteins is not only helpful in annotating function for proteins, but also very important for structure-based drug design and disease treatment. However, this is one of the most difficult tasks and current methods are constrained by some factors. In this study, we developed a new method to predict residue-residue contacts of two interacting protein domains by integrating information about evolutionary couplings andamino acid pairwise contact potentials, as well as domain-domain interaction interfaces. The experimental results showed that our proposed method outperformed the previous method with the same datasets. Moreover, the method promises an improvement in the source of template-based protein docking.Detailed knowledge of interfacial region between interacting proteins is not only helpful in annotating function for proteins, but also very important for structure-based drug design and disease treatment. However, this is one of the most difficult tasks and current methods are constrained by some factors. In this study, we developed a new method to predict residue-residue contacts of two interacting protein domains by integrating information about evolutionary couplings andamino acid pairwise contact potentials, as well as domain-domain interaction interfaces. The experimental results showed that our proposed method outperformed the previous method with the same datasets. Moreover, the method promises an improvement in the source of template-based protein docking.

关 键 词：Residue-Residue CONTACTS Domain-Domain INTERACTIONS PROTEIN-PROTEIN INTERACTIONS DOMAIN Interfaces RESIDUE Co-Evolution Contact Potentials 

分 类 号：R73[医药卫生—肿瘤]