Rapid and Non-Invasive Screening System for Early Detection of Diabetic Retinopathy via Auto Fluorescence of <i>Falvin</i>Proteins  

作　　者：Bin Gao Yang Li Qifeng Jiang 

机构地区：[1]Department of Medical Information, Chongqing Medical University, Chongqing, China [2]Department of Biochemistry and Molecular Biology, Chongqing Medical University, Chongqing, China

出　　处：《Journal of Biomedical Science and Engineering》2018年第8期215-224,共10页生物医学工程（英文）

摘　　要：Diabetic retinopathy is one of the most serious complications of diabetes, which is also one of the most important causes of blindness around the world. Autofluorescence of flavin protein in retinal pigment epithelial cells is considered as a marker of early tissue damage. This study was designed to image spontaneous fluorescence of falvin proteins in fundus macular center area. The average intensity of the fluorescence signal and the characteristics of the histogram distribution were obtained and the significant differences in the fluorescence signals between the diabetic and the normal people were also compared with statistical methods, and then a rapid and non-invasive screening method and equipment for early detection of diabetic retinopathy were developed.Diabetic retinopathy is one of the most serious complications of diabetes, which is also one of the most important causes of blindness around the world. Autofluorescence of flavin protein in retinal pigment epithelial cells is considered as a marker of early tissue damage. This study was designed to image spontaneous fluorescence of falvin proteins in fundus macular center area. The average intensity of the fluorescence signal and the characteristics of the histogram distribution were obtained and the significant differences in the fluorescence signals between the diabetic and the normal people were also compared with statistical methods, and then a rapid and non-invasive screening method and equipment for early detection of diabetic retinopathy were developed.

关 键 词：Diabetic RETINOPATHY FUNDUS MACULAR FLAVIN Protein Autofluorescence 

分 类 号：R73[医药卫生—肿瘤]