Hypoxic Condition Up-Regulates the Expression of Angiopoietin-2 in ADSCs  

作　　者：Lingxiao Ye Xiaoming Sun Yuguang Zhang Ying Zhang 

机构地区：[1]Department of Plastic and Reconstructive Surgery, The Ninth People’s Hospital Affiliated to School of Medicine Shanghai Jiao Tong University, Shanghai, China

出　　处：《Journal of Biomedical Science and Engineering》2019年第2期77-84,共8页生物医学工程（英文）

摘　　要：Wound healing requires abundant nutrition and blood supply, thus angiogenesis is a vital stage in this process. Angiogenesis involves diverse kinds of immune cells, growth factors, cytokines and inhibitors. ADSCs, especially ADSCs cultured in hypoxic condition, are reported to be able to facilitate angiogenesis and promote wound healing process. Significant efforts have been made on the development of ADSCs-based therapies with wound-healing applications. Here the results showed that expression of Angiopoietin-2 (ANGPT2) in ADSCs was up-regulated in the hypoxic condition.Wound healing requires abundant nutrition and blood supply, thus angiogenesis is a vital stage in this process. Angiogenesis involves diverse kinds of immune cells, growth factors, cytokines and inhibitors. ADSCs, especially ADSCs cultured in hypoxic condition, are reported to be able to facilitate angiogenesis and promote wound healing process. Significant efforts have been made on the development of ADSCs-based therapies with wound-healing applications. Here the results showed that expression of Angiopoietin-2 (ANGPT2) in ADSCs was up-regulated in the hypoxic condition.

关 键 词：ADSCS ANGPT2 ANGIOGENESIS WOUND HEALING 

分 类 号：R73[医药卫生—肿瘤]