Therapeutic Potential of Berberine in Type 2 Diabetes: A Short Review  

作　　者：Maha Aldosari Nehad Al-Shawi Noorah Saleh Al-Sowayan Maha Aldosari;Nehad Al-Shawi;Noorah Saleh Al-Sowayan(Department of Biology, College of Science, Qassim University, Buraydah, KSA)

机构地区：[1]Department of Biology, College of Science, Qassim University, Buraydah, KSA

出　　处：《Journal of Biomedical Science and Engineering》2024年第11期218-224,共7页生物医学工程（英文）

摘　　要：Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease that is influenced by genetic, metabolic, and environmental factors. Genetic predisposition, obesity, low physical activity, and unhealthy diet are key risk factors for T2DM. Result: Type 2 diabetes is treated with various natural medicines, the most significant of which is berberine (BBR). Berberine, an isoquinoline alkaloid found in various medicinal plants, exhibits a wide range of pharmacological activities and (BBR) has the potential to treat various diseases, such as diabetes, cancer, and metabolic and cardiovascular diseases. Conclusion: It has been found to be effective in AMPK activation, regulation of blood glucose and lipids, stimulation of insulin secretion from pancreatic beta cells, inhibition of cancer cells, and reduction of fat formation.Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial disease that is influenced by genetic, metabolic, and environmental factors. Genetic predisposition, obesity, low physical activity, and unhealthy diet are key risk factors for T2DM. Result: Type 2 diabetes is treated with various natural medicines, the most significant of which is berberine (BBR). Berberine, an isoquinoline alkaloid found in various medicinal plants, exhibits a wide range of pharmacological activities and (BBR) has the potential to treat various diseases, such as diabetes, cancer, and metabolic and cardiovascular diseases. Conclusion: It has been found to be effective in AMPK activation, regulation of blood glucose and lipids, stimulation of insulin secretion from pancreatic beta cells, inhibition of cancer cells, and reduction of fat formation.

关 键 词：Blood Glucose BERBERINE INSULIN Diabetes Mellitus Cancer Cells Oxidative Stress Blood Vessels 

分 类 号：R58[医药卫生—内分泌]