Synthesis of 4-[F-18]Fluoro-4-Deoxy-N-Acetyl-1,3,6-Tri-O-Acetylglucosamine, a Potential Brain Imaging PET Agent  

作　　者：Murthy Akula Derek Cressy Lee Collier George Kabalka Dustin Osborne Murthy Akula;Derek Cressy;Lee Collier;George Kabalka;Dustin Osborne(Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA;Advion Biosciences, Ithaca, USA)

机构地区：[1]Department of Radiology, The University of Tennessee Medical Center, Knoxville, USA [2]Advion Biosciences, Ithaca, USA

出　　处：《Natural Science》2024年第3期19-23,共5页自然科学期刊（英文）

摘　　要：The synthesis of a promising brain imaging agent 4-[F-18]fluoro-4-deoxy-N-acetyl-1,3,6-tri-O-acetylglucosamine, 2, was successfully accomplished from commercially available N-acetyl glucosamine in 5 steps. The non-decay corrected radiochemical yield and purity were found to be 31% ± 4% (n = 3) and >98% respectively. The total reaction time for radio labelling step was 50 min.The synthesis of a promising brain imaging agent 4-[F-18]fluoro-4-deoxy-N-acetyl-1,3,6-tri-O-acetylglucosamine, 2, was successfully accomplished from commercially available N-acetyl glucosamine in 5 steps. The non-decay corrected radiochemical yield and purity were found to be 31% ± 4% (n = 3) and >98% respectively. The total reaction time for radio labelling step was 50 min.

关 键 词：N-ACETYLGLUCOSAMINE AMYLOIDOGENESIS Lipase-Candida rugosa 

分 类 号：O62[理学—有机化学]