AMYLOIDOGENESIS

作品数：7被引量：13H指数：2
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相关领域：医药卫生生物学更多>>
相关期刊：《Neural Regeneration Research》《Journal of Sport and Health Science》《Science China Chemistry》《Chinese Medical Journal》更多>>
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Synthesis of 4-[F-18]Fluoro-4-Deoxy-N-Acetyl-1,3,6-Tri-O-Acetylglucosamine, a Potential Brain Imaging PET Agent
《Natural Science》2024年第3期19-23,共5页Murthy Akula Derek Cressy Lee Collier George Kabalka Dustin Osborne 
The synthesis of a promising brain imaging agent 4-[F-18]fluoro-4-deoxy-N-acetyl-1,3,6-tri-O-acetylglucosamine, 2, was successfully accomplished from commercially available N-acetyl glucosamine in 5 steps. The non-dec...
关键词：N-ACETYLGLUCOSAMINE AMYLOIDOGENESIS Lipase-Candida rugosa 
Butyrate acts as a G-protein-coupled receptor ligand that prevents high glucose-induced amyloidogenesis in N2a cells through the protein kinase B/glycogen synthase kinase-3β pathway
《Chinese Medical Journal》2023年第19期2368-2370,共3页Yujie Xu Shufang Shan Xiaoyu Wang Lingli Li Liang Ma Jingyuan Xiong Ping Fu Guo Cheng 
supported by grants from the Active Health and Aging Technologic Solutions Major Project of the National Key R&D Program(No.2020YFC2006300);the Department of Science and Technology of Sichuan Province(No.2021YJ0156);the West China Nursing Discipline Development Special Fund Project of Sichuan University(No.HXHL20006)
To the Editor:Alzheimer’s disease(AD)and type 2 diabetes mellitus(T2DM)are major causes of morbidity and mortality in older individuals,and their epidemiological link generates substantial challenges for the manageme...
关键词：AMYLOID metabolism MORTALITY 
Clusterin transduces Alzheimer-risk signals to amyloidogenesis被引量：4
《Signal Transduction and Targeted Therapy》2022年第10期3658-3661,共4页Xi Liu Rongbo Che Wenping Liang Yun Zhang Liyong Wu Chao Han Hong Lu Weihong Song Yili Wu Zhe Wang 
supported by National Natural Science Foundation of China(no.81870832);Beijing Committees of Education-Science Foundation of Beijing joint fund(no.KZ202010025040);“Wisdom Gathering”program of Xuanwu Hospital to Z.W.,National Natural Science Foundation of China(no.81771147 and 81971019);Y.W.,and National Natural Science Foundation of China(no.81600943)。
Dear Editor,Deposition of amyloid-β(Aβ)to form neuritic plaque(NP)is the hallmark of Alzheimer’s Disease(AD).Major non-genetic risk factors such as ageing,stroke,diabetes and other conditions facilitate AD pathogen...
关键词：ALZHEIMER AΒ CLUSTERIN 
Selective serotonin reuptake inhibitors and Alzheimer’s disease被引量：7
《Neural Regeneration Research》2020年第1期41-46,共6页Bernadette Mdawar Elias Ghossoub Rita Khoury 
Given the failure to develop disease-modifying therapies for Alzheimer’s disease(AD),strategies aiming at preventing or delaying the onset of the disease are being prioritized.While the debate regarding whether depre...
关键词：Alzheimer’s disease AMYLOIDOGENESIS animal models ANTIDEPRESSANT depression onset delay prevention selective SEROTONIN REUPTAKE inhibitor SSRI 
Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice被引量：2
《Translational Neurodegeneration》2019年第1期317-332,共16页Hyeon Joo Ham Sang-Bae Han Jaesuk Yun In Jun Yeo Young Wan Ham Se Hyun Kim Pil-Hoon Park Dong-Young Choi Jin Tae Hong 
This work was supported by the National Research Foundation of Korea(NRF)grant funded by Korea government(MSIP)(No.MRC,2017R1A5A2015541);was supported by Korea Institute for Advancement of Technology(KIAT)as the research project for World Class 300 R&D(WC300 R&D,No.S2563418).
Background:Neuroinflammation and accumulation ofβ-amyloid(Aβ)play a significant role in the onset and progression of Alzheimer’s disease(AD).Our previous study demonstrated that signal transducer and activator of t...
关键词：Bee venom phospholipase A2 Alzheimer’s disease AMYLOIDOGENESIS NEUROINFLAMMATION STAT3 
Surgical menopause enhances hippocampal amyloidogenesis following global cerebral ischemia
《Journal of Sport and Health Science》2014年第3期206-216,共11页Erin L.Scott Quan-Guang Zhang Yan Dong Dong Han Rui-Min Wang Ratna K.Vadlamudi Darrell W.Brann 
supported by a Pre-doctoral Fellowship from the American Heart Association to ELS.(12PRE11530009);a Research Grant from the National Institute of Neurological Disorders and Stroke;National Institutes of Health,USA to DWB(NS050730)
Background： Prematurely menopausal women have a doubled lifetime risk of dementia and a 5-fold increased risk of mortality from neuro- logical disorders, but the molecular mechanisms underlying these risks remain unc...
关键词：AMYLOID DEMENTIA ESTROGEN ISCHEMIA Surgical menopause 
3D-QSAR and docking studies on 2-arylbenzoxazole and linker-Y transthyretin amyloidogenesis inhibitors
《Science China Chemistry》2013年第11期1550-1563,共14页ZHAO LiJun ZHANG LiangRen LEI Ming 
supported by the National Natural Science Foundation of China(21072018);the Fundamental Research Funds for the Central Universities(ZY1213);the Foundation of State Key Laboratory of Natural and Biomimetic Drugs(K20120202)
Transthyretin(TTR),a plasma protein with a tetramer structure,could form amyloid fibril associated with several human diseases through the dissociation of tetramer and the misfolding of monomer.These amyloidogenesis c...
关键词：TRANSTHYRETIN 3D-QSAR 2-arylbenzoxazoles linker-Y DOCKING binding mode 
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