Unravelling the Functions of Regulatory T Cells during Infection  

作　　者：Tania Rahman Md Ferdous Seraj Annelise Casellato 

机构地区：[1]Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, Australia [2]Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia [3]School of Civil, Environmental and Chemical Engineering, RMIT University, Melbourne, Australia [4]Departamento de Química Inorganica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

出　　处：《Open Journal of Medical Microbiology》2018年第4期118-131,共14页医学微生物学（英文）

摘　　要：Accumulating evidences have suggested that Treg have an active role in the regulation of immunity to infection. Treg suppress not only autoimmune responses but also other immune responses for instance, during acute infections, against commensal microbes in inflammatory diseases or during chronic illness. Treg have been shown to limit exacerbated inflammation to avoid collateral tissue damage. Treg are also suggested to provide early protective responses in some viral infections as the permitting timely entry of effector cells in infected tissue. Furthermore, Treg have been shown to contribute to form memory pool after resolution of infection. In this review, we survey and analysis our current knowledge and relative dynamics of Treg in a wide range of infection settings and elaborate the examples in which these cells are of critical importance in conferring tolerance, suppressing pathogenesis, inducing protection and optimizing immunity to eliminate infection.Accumulating evidences have suggested that Treg have an active role in the regulation of immunity to infection. Treg suppress not only autoimmune responses but also other immune responses for instance, during acute infections, against commensal microbes in inflammatory diseases or during chronic illness. Treg have been shown to limit exacerbated inflammation to avoid collateral tissue damage. Treg are also suggested to provide early protective responses in some viral infections as the permitting timely entry of effector cells in infected tissue. Furthermore, Treg have been shown to contribute to form memory pool after resolution of infection. In this review, we survey and analysis our current knowledge and relative dynamics of Treg in a wide range of infection settings and elaborate the examples in which these cells are of critical importance in conferring tolerance, suppressing pathogenesis, inducing protection and optimizing immunity to eliminate infection.

关 键 词：TREG Suppression CD4 T-CELL RESPONSE CD8 T-CELL RESPONSE CD25+ TREG RAG-1-Deficient MICE Foxp3DTR MICE DEREG MICE COLONIC TREG 

分 类 号：R73[医药卫生—肿瘤]