Molecular Docking Studies of Alpinia galanga Phytoconstituents for Psychostimulant Activity  

作　　者：Santhy Sivanandan Surekha Pimple 

机构地区：[1]Avinashilingam Institute for Home Science and Higher Education for Women,Coimbatore,India [2]Enovate Biolife,Wilmington,DE,USA

出　　处：《Advances in Biological Chemistry》2018年第4期69-80,共12页生物化学进展（英文）

基　　金：We are obliged to Dr.Santhi Natchimuthu for her support and contribution in conducting this study.The authors are grateful to Mr.Jayesh Chaudhary(Enovate Biolife)for financial support

摘　　要：Dopamine is a neurotransmitter responsible for sending signals from the central nervous system. It allows human beings to stay attentive and focused. Caffeine, the most widely consumed psychoactive substance in the world, is known to improve alertness by enhancing dopamine signaling in the brain. EnXtra®, an Alpinia galanga extract has been clinically proven to promote alertness however the mechanism for such action required elucidation. The current study was designed to explore the mechanism for the neurocognitive enhancing property of EnXtra®by the in-silico interaction of its potential compounds with various targets involved in such process namely Dopamine and Acetylcholinesterase (AchE). As evident by the outcomes of the study, active compounds of EnXtra®can block the dopamine reuptake thereby increasing the dopamine levels which further can enhance the visuospatial performance and mental clarity, leading to improved mental alertness. At the same time, its strong effect on Acetylcholinesterase receptors is indicative of its nootropic potential.Dopamine is a neurotransmitter responsible for sending signals from the central nervous system. It allows human beings to stay attentive and focused. Caffeine, the most widely consumed psychoactive substance in the world, is known to improve alertness by enhancing dopamine signaling in the brain. EnXtra®, an Alpinia galanga extract has been clinically proven to promote alertness however the mechanism for such action required elucidation. The current study was designed to explore the mechanism for the neurocognitive enhancing property of EnXtra®by the in-silico interaction of its potential compounds with various targets involved in such process namely Dopamine and Acetylcholinesterase (AchE). As evident by the outcomes of the study, active compounds of EnXtra®can block the dopamine reuptake thereby increasing the dopamine levels which further can enhance the visuospatial performance and mental clarity, leading to improved mental alertness. At the same time, its strong effect on Acetylcholinesterase receptors is indicative of its nootropic potential.

关 键 词：EnXtra^■ CAFFEINE DOPAMINE Enovate Biolife Energy Drink COGNITIVE IN-SILICO 

分 类 号：R73[医药卫生—肿瘤]