Highly Efficient, One Pot Synthesis and Oxidation of Hantsch 1,4-Dihydropyridines Mediated by Iodobenzene Diacetate (III) Using Conventional Heating, Ultrasonic and Microwave Irradiation  

作　　者：Khalid Hussain Deepak Wadhwa 

机构地区：[1]Department of chemistry, Kurukshetra University, Kurukshetra, India [2]Mewat Engineering College (WAKF), Nuh, India

出　　处：《International Journal of Organic Chemistry》2014年第3期174-181,共8页有机化学国际期刊（英文）

摘　　要：A mild, general, convenient, and efficient one-pot synthesis of 4-arylpyridines (4) is described using conventional heating, ultrasound and microwave irradiation. Aryl aldehydes (2) were efficiently condensed with ethylacetoacetate (1) and ammonium acetate in acetonitrile to give dihydropyridine intermediates (4). The latter underwent a smooth Iodobenzene Diacetate (III) mediated aromatization reaction in the same pot to afford 4-arylpyridines (4) in good to excellent yields.A mild, general, convenient, and efficient one-pot synthesis of 4-arylpyridines (4) is described using conventional heating, ultrasound and microwave irradiation. Aryl aldehydes (2) were efficiently condensed with ethylacetoacetate (1) and ammonium acetate in acetonitrile to give dihydropyridine intermediates (4). The latter underwent a smooth Iodobenzene Diacetate (III) mediated aromatization reaction in the same pot to afford 4-arylpyridines (4) in good to excellent yields.

关 键 词：DIHYDROPYRIDINES IODOBENZENE DIACETATE ULTRASONIC Microwave One-Pot Formylpyrazoles 

分 类 号：O6[理学—化学]