Novel Route for Synthesis of Thiozolidine-2,4-Dione Derivatives as a Mannich Base  

作　　者：Ramakrishna Vellalacheruvu Ramayanam Sai Leela L. K. Ravindranath 

机构地区：[1]Department of Chemistry, Sri Krishnadevaraya University, Anantapur, India

出　　处：《International Journal of Organic Chemistry》2017年第3期269-283,共15页有机化学国际期刊（英文）

摘　　要：The Mannich base of Thiozolidine-2,4-dione derivatives has come to lime light due to their various pharmacological activities. Thiazolidine-2,4-dione is an extensively explored heterocyclic nucleus for designing of novel agents implicated for a wide variety of pathophysiological conditions, that is, diabetes, diabetic complications, cancer, arthritis, inflammation, microbial infection, and melanoma. In present work, synthesis quinoline attached imidazoline derivative using (3 + 2) cyclo-addition via imine of quinoline and TosMIC. These derivatives were converted to Mannich bases of thiozolidine-2,4-dione using Knoevenagel condensation. The sulfonamide analogues of thiozolidine-2,4-Dione were also synthesized and characterized by using alkylation conditions.The Mannich base of Thiozolidine-2,4-dione derivatives has come to lime light due to their various pharmacological activities. Thiazolidine-2,4-dione is an extensively explored heterocyclic nucleus for designing of novel agents implicated for a wide variety of pathophysiological conditions, that is, diabetes, diabetic complications, cancer, arthritis, inflammation, microbial infection, and melanoma. In present work, synthesis quinoline attached imidazoline derivative using (3 + 2) cyclo-addition via imine of quinoline and TosMIC. These derivatives were converted to Mannich bases of thiozolidine-2,4-dione using Knoevenagel condensation. The sulfonamide analogues of thiozolidine-2,4-Dione were also synthesized and characterized by using alkylation conditions.

关 键 词：IMIDAZOLE ANALOGUES Thiozolidine-2 4-Dione Nucleus Toluenesulfonylmethyl ISOCYANIDE Combi-Flash Column Chromatography 

分 类 号：O6[理学—化学]