Recent Advances in Photoenzymatic Catalysis  

作　　者：Caiyi Xiang Caiyi Xiang(School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA)

机构地区：[1]School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA

出　　处：《International Journal of Organic Chemistry》2024年第2期69-91,共23页有机化学国际期刊（英文）

摘　　要：Photoenzymatic catalysis has become an emerging field in organic synthetic chemistry that provides eco-friendly alternatives to traditional methods. This comprehensive review examines the developing field of photoenzymatic catalysis, categorized by reaction types and focusing on its application in organic synthesis. This article highlights recent advances in the use of photoenzymatic reactions in carbon-carbon cross-coupling, ketone and alkene reduction, hydroamination, and hydrosulfonylation, mostly by flavin-dependent “ene”-reductases and nitroreductases. In each case, we exemplified the substrate scope that produces products with high yield and enantioselectivity. Additionally, the emerging trends in developing new enzymatic variants and novel reaction pathways that broaden the scope and enhance yield of these reactions were discussed.Photoenzymatic catalysis has become an emerging field in organic synthetic chemistry that provides eco-friendly alternatives to traditional methods. This comprehensive review examines the developing field of photoenzymatic catalysis, categorized by reaction types and focusing on its application in organic synthesis. This article highlights recent advances in the use of photoenzymatic reactions in carbon-carbon cross-coupling, ketone and alkene reduction, hydroamination, and hydrosulfonylation, mostly by flavin-dependent “ene”-reductases and nitroreductases. In each case, we exemplified the substrate scope that produces products with high yield and enantioselectivity. Additionally, the emerging trends in developing new enzymatic variants and novel reaction pathways that broaden the scope and enhance yield of these reactions were discussed.

关 键 词：Photoenzymatic BIOCATALYSIS BIOCATALYSTS ERED “Ene”-Reductases Nitroreductases FLAVIN 

分 类 号：O64[理学—物理化学]