The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study  

作　　者：William N. Setzer 

机构地区：[1]Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA

出　　处：《Journal of Biophysical Chemistry》2011年第2期135-136,共2页生物物理化学（英文）

摘　　要：The epsilon class glutathione-S-transferase of Anopheles gambiae, agGSTe2, is capable of metabolizing DDT. A molecular docking analysis of DDT with agGSTe2 support an E2 elimination mechanism wherein the glutathione sulfur serves as the base to convert DDT to DDE.The epsilon class glutathione-S-transferase of Anopheles gambiae, agGSTe2, is capable of metabolizing DDT. A molecular docking analysis of DDT with agGSTe2 support an E2 elimination mechanism wherein the glutathione sulfur serves as the base to convert DDT to DDE.

关 键 词：Malaria DDT ANOPHELES GAMBIAE GLUTATHIONE S-TRANSFERASE Docking 

分 类 号：R73[医药卫生—肿瘤]