Synthesis and X-Ray Structure of Important Anticancer Nucleosides Intermediate (2<i>R</i>,3<i>S</i>,4<i>S</i>,5<i>R</i>)-2-(acetoxymethyl)-5- (3-bromo-5-(methoxycarbonyl)- 1<i>H</i>-1,2,4-triazol-1-yl)tetrahydrofuran- 3,4-diyl Diacetate  

作　　者：Yang Liu Guanghui Tian Hongguang Ge Xiaoyan Cao Daihua Hu Dehua Zhang 

机构地区：[1]Department of Chemistry and Environmental Engineering, Hubei Normal University, Huangshi, China [2]School of Chemistry and Environmental Science, Shaanxi University of Technology, Hanzhong, China

出　　处：《Journal of Crystallization Process and Technology》2014年第3期140-144,共5页结晶过程及技术期刊（英文）

摘　　要：An important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.An important anticancer nucleosides intermediate (2R,3S,4S,5R)-2-(acetoxymethyl)-5-(3-bromo-5-(methoxycar-bonyl)-1H-1,2,4-triazol-1-yl)tetrahydrofuran-3,4-diyl diacetate was synthesized by directly coupling the bromotriazole with the protected ribose sugar, and have given the corresponding product in moderate yield. Its structure and conformation were confirmed by single crystal X-ray diffraction.

关 键 词：ANTICANCER NUCLEOSIDES INTERMEDIATE Triazole NUCLEOSIDES 

分 类 号：O6[理学—化学]