Microwave Assisted Peptide Synthesis as a New Gold Standard in Solid Phase Peptide Synthesis: Phospholamban as an Example  

作　　者：Shadi Abu-Baker Philip Garber Bryce Hina Trevor Reed Ghaffari Shahrokh Mohannad Al-Saghir Gary Lorigan 

机构地区：[1]College of Arts and Sciences, Ohio University, Zanesville, USA [2]College of Arts and Sciences, Ohio University, Zanesville, USA Genesis Hospital, Ohio University, Zanesville, USA [3]Department of Chemistry and Biochemistry, Miami University, Oxford, USA

出　　处：《Open Journal of Synthesis Theory and Applications》2014年第1期1-4,共4页合成理论与应用（英文）

摘　　要：In this study, we report the microwave assisted synthesis of Phospholamban protein (WT-PLB) as a new gold standard in solid phase peptide synthesis. Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis. The use of microwave energy for both the coupling and deprotection steps makes the microwave peptide synthesizers the most versatile and powerful systems available. It produces high yield and fast synthesis when compared to conventional peptide synthesizers.In this study, we report the microwave assisted synthesis of Phospholamban protein (WT-PLB) as a new gold standard in solid phase peptide synthesis. Microwave energy offers benefits for both the coupling and deprotection reactions during peptide synthesis. The use of microwave energy for both the coupling and deprotection steps makes the microwave peptide synthesizers the most versatile and powerful systems available. It produces high yield and fast synthesis when compared to conventional peptide synthesizers.

关 键 词：SOLID-STATE PEPTIDE SYNTHESIS PHOSPHOLAMBAN Microwave Assisted SYNTHESIS 

分 类 号：O6[理学—化学]