PHOSPHOLAMBAN

作品数：15被引量：42H指数：5
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相关领域：医药卫生更多>>
相关作者：唐朝枢吴立玲杨青石晓静刘宏民更多>>
相关机构：郑州大学北京医科大学学研究院更多>>
相关期刊：《Acta Pharmacologica Sinica》《Advances in Biological Chemistry》《Open Journal of Synthesis Theory and Applications》《Phenomics》更多>>
相关基金：国家自然科学基金上海市科学技术发展基金更多>>
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A Heterozygous Phospholamban Variant(p.R14del)Leads to Left Ventricular Involvement and Heart Failure Phenotypes in Arrhythmogenic Right Ventricular Cardiomyopathy
《Phenomics》2024年第1期13-23,共11页Han Mo Xiumeng Hua Mengni Bao Zhe Sun Xiao Chen Mengda Xu Jiangping Song 
the National Natural Science Foundation for Distinguished Young Scholars of China(Grant No.82125004);the Shenzhen Science and Technology Innovation Commission(Grant No.JCYJ20220818103414030);the National Natural Science Foundation of China(Grant No.82300397);the key project of Shenzhen Basic Research Program(Natural Science Foundation of Shenzhen,Grant No.20220241);the Program for Guangdong Introducing Innovative and Enterpreneurial Teams(Grant No.2019ZT08Y481).
This study aimed to determine the prevalence and clinical features of Arrhythmogenic Right Ventricular Cardiomyopathy(ARVC)caused by pathogenic mutations in the Phospholamban(PLN)gene.The study included 170 patients w...
关键词：Arrhythmogenic right ventricular cardiomyopathy PHOSPHOLAMBAN Left ventricular involvement Heart failure Risk stratifcation 
Differential localizations of protein phosphatase 1 isoforms determine their physiological function in the heart
《Acta Biochimica et Biophysica Sinica》2019年第3期323-330,共8页Ruijie Liu Christian Miller Christiana D'Annibale Kimberly Vo Ashley Jacobs 
Protein phosphatase 1 isoforms α,β,and γ(PP1α,PP1β,and PP1γ)are highly homologous in the catalytic domains but have distinct subcellular localizations.In this study,we utilized both primary cell culture and knoc...
关键词：cardiac function HISTONE DEACETYLASE PHOSPHOLAMBAN protein PHOSPHATASE 1 
C33（S）, a novel PDE9A inhibitor, protects against rat cardiac hypertrophy through upregulating cGMP signaling被引量：6
《Acta Pharmacologica Sinica》2017年第9期1257-1268,共12页Pan-xia WANG Zhuo-ming LI Si-dong CAI Jing-yan LI Ping HE Yi HUANG Guo-shuai FENG Hai-bin LUO Shao-rui CHEN Pei-qing LIU 
Phosphodiesterase-9A （PDE9A） expression is upregulated during cardiac hypertrophy and heart failure. Accumulating evidence suggests that PDE9A might be a promising therapeutic target for heart diseases. The present ...
关键词：cardiac hypertrophy CARDIOMYOCYTES PDE9A C33（S） PF-7943 CGMP PHOSPHOLAMBAN SERCA2A 
Microwave Assisted Peptide Synthesis as a New Gold Standard in Solid Phase Peptide Synthesis: Phospholamban as an Example
《Open Journal of Synthesis Theory and Applications》2014年第1期1-4,共4页Shadi Abu-Baker Philip Garber Bryce Hina Trevor Reed Ghaffari Shahrokh Mohannad Al-Saghir Gary Lorigan 
In this study, we report the microwave assisted synthesis of Phospholamban protein (WT-PLB) as a new gold standard in solid phase peptide synthesis. Microwave energy offers benefits for both the coupling and deprotect...
关键词：SOLID-STATE PEPTIDE SYNTHESIS PHOSPHOLAMBAN Microwave Assisted SYNTHESIS 
抗氧化蛋白PrxⅡ对心肌收缩力的调控及其机制研究
《中国动脉硬化杂志》2013年第9期I0010-I0010,共1页石晓静 吕文营 刘宏民 EvangeliaG.Kranias 赵文 
国家自然科学基金（81270270）;郑州大学海外引进人才科研启动资金;河南省教育厅科技创新杰出人才基金（13HASTIT029）支持
目的过氧化氢过氧化物酶（peroxiredoxinⅡ，PrxⅡ）主要位于细胞的胞浆，可将体内多余的过氧化氢还原为水，PrxII属于过氧化氢过氧化物酶超家族成员之一，其余成员还有PrxI、Ⅲ、Ⅳ、V和Ⅵ，我们前期的研究发现：PrxⅡ可以保护氧化应...
关键词：PeroxiredoxinⅡ心肌收缩 钙瞬变 PHOSPHOLAMBAN 
Phospholamban Antisense RNA Improves SR Ca^(2+)-ATPase Activity and Left Ventricular Function in STZ-induced Diabetic Rats被引量：2
《Biomedical and Environmental Sciences》2013年第7期577-583,共7页LI Jiang JIA Bao Hui SUN Jian LOU Xiao Liang HU Shen Jiang 
supported by Scientific Research Foundation of College of Medicine,Zhejiang University;Foundation of Zhejiang Science and Technology Bureau(No.2007B071);Foundation of Zhejiang Educational Committee(No.Y200908338);Foundation of Zhejiang Traditional Chinese Medicine Committee(No.2011B503103)
Objective To study the effect of phospholamban antisense RNA （asPLB） on sarcoplasmic reticulum Ca2＋-ATPase activity and cardiac function in rats with diabetes mellitus （DM） mediated by recombinant adeno-associate...
关键词：Diabetes mellitus PHOSPHOLAMBAN Sarcoplasmic reticulum Ca2＋-ATPase  Gene therapy 
Improved Solid-Phase Peptide Synthesis of Wild-Type and Phosphorylated Phospholamban Using a Pseudoproline Dipeptide
《Open Journal of Synthesis Theory and Applications》2012年第2期9-12,共4页Shadi Abu-Baker Gary A. Lorigan 
In this study, we report that the insertion of a pseudoproline dipeptide for the solid-phase peptide synthesis of wild-type Phospholamban protein (WT-PLB) has two important advantages. First, it disrupts the formation...
关键词：SOLID-STATE PEPTIDE SYNTHESIS Pseudoproline DIPEPTIDE PHOSPHOLAMBAN 
Endogenous modulators in the regulation of ion transporting enzymes: structure, function, interactions, recent advancements and future perspectives
《Advances in Biological Chemistry》2011年第3期74-92,共19页Parimal C. Sen 
A prerequisite for life is the ability to uphold electro-chemical imbalance across biomembranes. Ion trans- porting enzymes, known as specific pumps, are re-sponsible for the transport of various ions across cell memb...
关键词：ATPASES ENDOGENOUS Protein/Peptides FX- YD PHOSPHOLAMBAN SARCOLIPIN INTERLEUKIN Regulations. 
The structure of phospholamban and its MD simulations
《Chinese Science Bulletin》2010年第16期1619-1624,共6页TANG Bei GONG Ke WANG JingFang LI YiXue WEI DongQing 
supported by the National Natural Science Foundation of China (20773085 and 30870476);National High-Tech Research and Devel-opment Program of China (2007AA02Z333);Major Chinese National Funding of New Drug Discovery for the Integrated Platform
Phospholamban is an important protein with responsibility for regulating the activity of the sarcoplasmic reticulum Ca2+ pump through reversible phosphorylation.And its three-dimensional structure in living cell has b...
关键词：分子动力学模拟 可逆磷酸化 三维结构 结构系统 实验确定 螺旋结构 基因突变 蛋白结构 
CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity被引量：8
《Acta Pharmacologica Sinica》2010年第2期165-174,共10页Min-you QI Yu FENG De-zai DAI Na LI Yu-si CHENG Yin DAI 
Aim： To investigate whether CPU86017, a berberine derivative, attenuates heart failure by blocking calcium influx and exerting its antioxidant activity. Methods： Myocardial infarction was induced in male Sprague-Daw...
关键词：BERBERINE FKBP12.6 SERCA2a heart failure calcium leakage endothelin oxidative stress PHOSPHOLAMBAN Sprague- Dawley rats 
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