supported by the National Natural Science Foundation of China(81970202,81903609,U21A20339);the Natural Science Foundation of Heilongjiang Province,China(LH2022H002);the Outstanding Young Talent Research Fund of College of Pharmacy,Harbin Medical University(2019-JQ-02);2021(the second batch)Research Funds for affiliated research institutes in Heilongjiang Province(CZKYF2021-2-C013).
Cardiac conduction regulatory RNA(CCRR)has been documented as an antiarrhythmic lncRNA in our earlier investigation.This study aimed to evaluate the effects of CCRR on SERCA2a and the associated Ca^(2+)homeostasis in ...
supported by the National Natural Science Foundation of China (82273928,U21A20339);the Outstanding Youth Project of Natural Science Foundation of Heilongjiang Province (YQ2020H010);Youth Project of Scientific Research Institution of Heilongjiang Province (CZKYF2023-1-C047);CAMS Innovation Fund for Medical Sciences (CIFMS) (2019-I2M-5-078);Harbin Medical University Youth Talents Start-up Funding (2019-YQ-03)。
Ischemic heart failure(HF)remains a leading cause of morbidity and mortality.Maintaining homeostasis of cardiac function and preventing cardiac remodeling deterioration are critical to halting HF progression.Methyltra...
supported by grants from the Natural Science Foundation of Jiangsu Province(No.BK20190988);the Scientific Research Project of Jiangsu Health Committee(No.H2018005);the Key Research and Development Program of Xuzhou(No.KC20097);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX21_2671).
Background:Sarcoplasmic reticulum calcium ATPase 2a(SERCA2a)is a key protein that maintains myocardial Ca2+homeostasis.The present study aimed to investigate the mechanism underlying the SERCA2a-SUMOylation(small ubiq...