云南高校图书馆联盟文献共享服务平台- C-CBL

C-CBL: 作品数：41被引量：108H指数：6; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：刘云鹏曲秀娟李琳琳胡雪君侯科佐更多>>; 相关机构：中国医科大学中国医科大学附属第一医院苏州大学辽宁省肿瘤医院更多>>; 相关期刊：《肿瘤预防与治疗》《Science China(Life Sciences)》《东南大学学报（医学版）》《四川医学》更多>>; 相关基金：国家自然科学基金辽宁省自然科学基金国家重点基础研究发展计划北京市自然科学基金更多>>

泛素化连接酶c-Cbl对急性髓系白血病细胞增殖分化能力的影响: 《蚌埠医学院学报》2024年第10期1271-1275,1281,共6页汪晶张佳琳田文静马丽高佳张英杰李玉云; 安徽省高校研究生科研项目(YJS20210532)。; 目的:探讨泛素化连接酶c-Cbl对急性髓系白血病细胞株THP-1细胞(人急性单核细胞白血病细胞)增殖分化能力的影响。方法:构建并筛选出稳定转染HBLV-h-CBL-ZsGreen-PURO敲低和HBLV-h-CBL-HA-BSD过表达病毒载体的THP-1细胞,分为4组:NC组(c-Cb...; 关键词：髓系白血病细胞株 C-CBL 增殖凋亡分化

新风胶囊含药血清通过调控环状RNA Cbl原癌基因B(circ-CBLB)影响类风湿关节炎滑膜成纤维细胞增殖和凋亡: 《细胞与分子免疫学杂志》2024年第9期792-799,共8页李舒万磊刘健黄传兵李方泽程静胡赛赛陈莹莹朱子衡; 国家中医药管理局第七批全国老中医药专家学术经验继承项目(国中医药人教函[2022]76号)。国家自然科学基金面上项目(81973655,82274501);安徽省高校优秀青年人才支持计划项目(皖教秘人[2022]11号);新安医学教育部重点实验室(2020xayx04);安徽省高校自然科学研究项目(KJ2020A0397);安徽省新时代育人质量工程项目(2022xscx103)。; 目的探讨新风胶囊(XFC)含药血清通过调控环状RNA Cbl原癌基因B(circ-CBLB)对类风湿关节炎成纤维细胞样滑膜细胞(RA-FLS)增殖、凋亡的影响。方法XFC灌胃大鼠,制备含药血清。人RA-FLS来源于RA患者滑膜组织,用100μL的10 ng/mL肿瘤坏死因子...; 关键词：新风胶囊(XFC) 环状RNA Cbl原癌基因B(circ-CBLB) 成纤维细胞样滑膜细胞(FLS) 细胞增殖细胞凋亡细胞因子

基于FC联合CBL教学模式在重症医学临床带教中的应用研究: 《中文科技期刊数据库(文摘版)教育》2024年第8期186-189,共4页孙宗发怀素丽; 安徽省教育厅高等学校质量工程省级项目,项目编号2022jyxm875。; 深入分析FC协同CBL教学法在重症医学科临床实习中的实践与应用探究。方法选择在安徽中医药大学第二附属医院重症医学科实习的中医临床专业本科生80名,通过严谨的随机双盲数字分配法,分为对照组与实验组,每组各40名。对照组沿用常规教...; 关键词：FC-CBL教学模式重症医学应用研究

SUV39H1-driven NFATc1 methylation is essential for the c-Cbl-mediated degradation of NFATc1 in an osteoclast lineage: 《Genes & Diseases》2024年第4期86-89,共4页Do-Won Jeong Hye-Jin Kim Jong-Wan Park Seulbee Lee Hyeryeon Jung Eugene C.Yi Nacksung Kime Yang-Sook Chun; supported by the National Research Foundation of Korea(No.2019R1A2C2083886,2018R1A5A20-25964);supported by the Cooperative Research Program of Basic Medical Science and Clinical Science from Seoul National University College of Medicine(No.800-20220312).; Bone undergoes continuous remodeling by tightly-coordinated actions of bone-resorbing osteoclasts and boneforming osteoblasts.1 Recent studies document that the dysregulation of histone methylation profiles is associa...; 关键词：OSTEOCLAST REMODELING INCOMPLETE

SERPINE2 promotes liver cancer metastasis by inhibiting c-Cbl-mediated EGFR ubiquitination and degradation被引量：2: 《Cancer Communications》2024年第3期384-407,共24页Shiyu Zhang Xing Jia Haojiang Dai Xingxin Zhu Wenfeng Song Suchen Bian Hao Wu Shinuo Chen Yangbo Tang Junran Chen Cheng Jin Mengqiao Zhou Haiyang Xie Shusen Zheng Penghong Song; This work was supported by grants from the National Nat-ural Science Foundation of China(82070652 and 81870434);Department of Science and Technology of Zhejiang Province(2020C04003);the Chinese Academy of Medi-cal Sciences(019-I2M-5-030);the Jinan Microecological Biomedicine Shandong Laboratory(JNL-2022007B);the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases(zz202302).; Background:Liver cancer is a malignancy with high morbidity and mortality rates.Serpin family E member 2(SERPINE2)has been reported to play a key role in the metastasis of many tumors.In this study,we aimed to investi...; 关键词：liver cancer METASTASIS DNA methylation SERPINE2 EGFR C-CBL UBIQUITINATION

靶向人c-Cbl基因重组干扰慢病毒与过表达腺病毒载体的构建、鉴定以及病毒功效研究被引量：2: 《中国实验血液学杂志》2024年第1期274-281,共8页孙启鑫吴秉毅姚倩倩黄志伟朱志刚; 广东省医学科研基金(A2019508);广东省高水平大学建设项目(LC2016ZD026);广州市医学重点学科项目(ZDXK202103)。; 目的:构建可调控c-Cbl基因表达的重组慢病毒与腺病毒并评估其功效。方法:应用基因重组技术,分别构建靶向人c-Cbl基因的干扰慢病毒和过表达腺病毒。采用定量PCR和免疫印迹法检测病毒感染后白血病细胞(HL60、THP1)c-Cbl基因表达与转录本...; 关键词：c-Cbl基因慢病毒载体腺病毒载体

Mettl13 protects against cardiac contractile dysfunction by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in ischemic heart failure被引量：1: 《Science China(Life Sciences)》2023年第12期2786-2804,共19页Shuting Yu ZhiYong Sun Xiuzhu Wang Tiantian Ju Changhao Wang Yingqi Liu Zhezhe Qu KuiWu Liu Zhongting Mei Na Li Meixi Lu Fan Wu Min Huang Xiaochen Pang Yingqiong Jia Ying Li Yaozhi Zhang Shunkang Dou Jianhao Jiang Xin Li Baofeng Yang Weijie Du; supported by the National Natural Science Foundation of China (82273928,U21A20339);the Outstanding Youth Project of Natural Science Foundation of Heilongjiang Province (YQ2020H010);Youth Project of Scientific Research Institution of Heilongjiang Province (CZKYF2023-1-C047);CAMS Innovation Fund for Medical Sciences (CIFMS) (2019-I2M-5-078);Harbin Medical University Youth Talents Start-up Funding (2019-YQ-03)。; Ischemic heart failure(HF)remains a leading cause of morbidity and mortality.Maintaining homeostasis of cardiac function and preventing cardiac remodeling deterioration are critical to halting HF progression.Methyltra...; 关键词：heart failure Mettl13 SERCA2A C-CBL UBIQUITINATION

circ-CBLB/miR-486-5p在脾虚湿盛型类风湿关节炎患者中的异常表达及意义被引量：3: 《海南医学院学报》2023年第17期1324-1331,共8页李舒万磊刘健黄传兵陈莹莹李方泽胡赛赛程静; 国家中医药管理局第七批全国老中医药专家学术经验继承项目(国中医药人教函[2022]76号);国家自然基金面上项目(81973655);国家自然基金面上项目(82274501);安徽省高校优秀青年人才支持计划项目(皖教秘人[2022]11号);新安医学教育部重点实验室(2020xayx04);安徽省高校自然科学研究项目(KJ2020A0397);安徽省新时代育人质量工程项目(2022xscx103)。; 目的:探讨circ-CBLB/miR-486-5p在脾虚湿盛型类风湿关节炎患者中的异常表达及意义。方法:纳入的30例健康者来自安徽省中医院体检中心,纳入的60例类风湿关节炎患者来自安徽中医药大学第一附属医院。类风湿关节炎患者的疾病活动评分采用VA...; 关键词：类风湿关节炎 circ-CBLB miR-486-5p 炎症极化脾虚湿盛证

Abnormal expression and significance of circ-CBLB/miR-486-5p in patients with rheumatoid arthritis of spleen deficiency and dampness excess type: 《Journal of Hainan Medical University》2023年第17期43-49,共7页LI Shu WAN Lei LIU Jian HUANG Chuan-bing CHEN Ying-ying LI Fang-ze HU Sai-sai CHENG Jing; the Seventh Batch of Inheritance Project of Academic Experience of National Veteran TCM Experts of the National Administration of Traditional Chinese Medicine (GZYYRJH[2022]No. 76);National Natural Science Foundation General Project (No.81973655);National Natural Science Foundation General Project (No.82274501);Anhui Provincial Excellent Youth Talent Support Program for Universities (Anhui Education Secretary [2022]No. 11);Key Laboratory of Xin'an Medical Education Department (No.2020xayx04);Natural Science Research Project of Universities in Anhui Province (No.KJ2020A0397);Anhui NewEra Education Quality Engineering Project (No.2022xscx103)。; Objective:To explore the abnormal expression and significance of circ-CBLB/miR-486-5p in patients with rheumatoid arthritis of spleen deficiency and dampness excess type.Methods:The 30 healthy individuals included in ...; 关键词：Rheumatoid arthritis circ-CBLB MiR-486-5p Inflammatory polarization Spleen deficiency and dampness excess syndrome

LncRNA MIR31HG controls the proliferation and metastasis of gastric cancer by c-CBL-mediated degradation of β-catenin被引量：1: 《Genes & Diseases》2023年第3期712-715,共4页Wen Peng Jiayi Zhang Shenghao Wang Feng Wang a Kun Wang Rui Geng Xiangfei Ding Jingping Zhang Biao Li Xiaoxue Ke Muhan Lü Hongjuan Cui; supported by the Natural Science Foundation of Chongqing(China)(No.cstc2019jcyj-zdxmX0033).; LncMIR31HG acts as a host gene for miR-31,also known as LncHIFCAR(long non-coding HIF-1 co-activating RNA),whose deregulation has been reported to promote the development of various human cancers,including lung cancer...; 关键词：cancer METASTASIS GASTRIC

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