国家重点基础研究发展计划(2010CB945301)

作品数:3被引量:12H指数:2
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相关作者:邵丽娟吴婷婷赵勇王若雨更多>>
相关机构:大连大学附属中山医院中国科学院更多>>
相关期刊:《Cellular & Molecular Immunology》《国际肿瘤学杂志》更多>>
相关主题:MACROPHAGESDONORALLOGENEICTRANSPLANTRECIPIENT更多>>
相关领域:医药卫生生物学更多>>
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髓系抑制性细胞与肿瘤被引量:2
《国际肿瘤学杂志》2013年第5期332-335,共4页邵丽娟 王若雨 吴婷婷 赵勇 
科技部国家重点基础研究发展计划(2010CB945301)
髓系抑制性细胞(MDSC)是一群髓系来源具有抑制功能的天然免疫细胞,在肿瘤进展中发挥负向免疫调控作用。MDSC具有强大的抑制功能及显著的异质性,通过多种机制调控固有免疫及适应性免疫系统,发挥促肿瘤作用,同时可通过非免疫机制促...
关键词:肿瘤 髓系细胞 髓系抑制性细胞 靶向治疗 
nduction of M2-1ike macrophages in recipient NOD-scid mice by allogeneic donor CD4+CD25+ regulatory T cells被引量:6
《Cellular & Molecular Immunology》2012年第6期464-472,共9页Xuelian Hu Guangwei Liu Yuzhu Hou Jianfeng Shi Linnan Zhu Di Jin Jianxia Peng Yong Zhao 
The authors wish to thank Drs Shuping Zhou and Zeqing Niu for their kind review of the manuscript, Ms ling Wang, Mr Yabing Liu and Ms Xiaoqiu Liu for their expert technical assistance, Ms Qinghuan Li and ]ianxia Peng for their excellent laboratory management and Mr Baisheng Ren for his outstanding animal husbandry. This work was supported by grants from the National Natural Science Foundation (C81072396, U0832003, YZ; C31171407 and 81273201, GL), the Ministry of Science and Technology of China (2010CB945301, YZ) and the Chinese Academy of Sciences for Distinguished Young Scientists (KSCX2-EW-Q-7, GL).
CD4+CD25+ regulatory T cells (Tregs) play an important role in maintaining host immune tolerance via regulation of the phenotype and function of the innate and adaptive immune cells. Whether allogeneic CD4+CD25+...
关键词:alternatively activated macrophages ARGINASE classically activated macrophages immune tolerance mouse transplanta-tion 
Alterations of peripheral CD4^(+)CD25^(+)Foxp3^(+)T regulatory cells in mice with STZ-induced diabetes被引量:4
《Cellular & Molecular Immunology》2012年第1期75-85,共11页Yu Zhen Lina Sun He Liu Kaizhong Duan Chun Zeng Lianjun Zhang Di Jin Jianxia Peng Wenjun Ding Yong Zhao 
grants from the National Basic Research Program of China(973 program,2010CB945301);National Natural Science Foundation for Key Programs(30630060).
Complications arising from abnormal immune responses are the major causes of mortality and morbidity in diabetic patients.CD4^(+)CD25^(+)T regulatory cells(Tregs)play pivotal roles in controlling immune homeostasis,im...
关键词:CD4^(+)CD25^(+)Foxp3^(+)T regulatory T cells DIABETES HYPERGLYCEMIA immune disorder MICE 
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