This work was supported by grants from the Eleventh Five-Year Plan for AIDS and viral hepatitis,prevention and treatment of infectious diseases and other major science and technology(No.2008ZX10002-004);the Ministry of Health Clinical Disciplines(No.20073531);the National Natural Science Foundation of China(No.30771912,30972610 and 30972611);Jilin Province Science and Technology Agency(No.200705128);a BMS grant for manuscript development.
Chronicity of hepatitis B(CHB)infection is characterized by a weak immune response to the virus.Entecavir(ETV)and adefovir dipivoxil(ADV)are effective in suppressing hepatitis B virus(HBV)replication.However,the under...