国家自然科学基金(31030030)

作品数:5被引量:3H指数:1
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相关作者:高福施一刘传省严景华张水军更多>>
相关机构:中国科学院中国科学院研究生院安徽农业大学更多>>
相关期刊:《生物工程学报》《Journal of Central South University》《Protein & Cell》更多>>
相关主题:蛋白折叠MONOCLONAL_ANTIBODYGP96FUSIONCDR3更多>>
相关领域:生物学农业科学电气工程医药卫生更多>>
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Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains被引量:1
《Protein & Cell》2014年第8期603-615,共13页Peipei Liu Di Liu Xi Yang Jing Gaoai Ma3, Fangqing Zhaos, Xuyu Zhou~'2~, George F. Gao1'2'4'5~, Baoli Zhu~'2~ Yan Chen Xue Xiao Fei Liu Jing Zou Jun Wu Juncai Ma Fangqing Zhao Xuyu Zhou George F. Gao Baoli Zhu 
We thank Dr. Christopher J. Vavrickafor and Boris Tefsen for their critical reading and revision of the manuscript and Dr. Miles P. Dav- enport for his inspiring discussions. This work is supported by the National Natural Science Foundation of China (NSFC, Grant No. 31030030), the National Basic Research Program (973 Program) (No. 2013CB531500) and the National Natural Science Foundation of China (Grant No. 81373141 ). G.F.G. is a leading principal investigator of the NSFC Innovative Research Group (Grant No. 81321063).
The characterization of the human T-cell receptor (TCR) repertoire has made remarkable progress, with most of the work focusing on the TCRβ chains. Here, we ana- lyzed the diversity and complexity of both the TCRa ...
关键词:TCR repertoire next-generationsequencing V/J usage V-J pairing CDR3 D-D fusion 
Crystal structures of the two membrane-proximal Ig-like domains(D3D4)of LILRB1/B2:alternative models for their involvement in peptide-HLA binding
《Protein & Cell》2013年第10期761-770,共10页Gol Nam Yi Shi Myongchol Ryu Qihui Wang Hao Song Jun Liu Jinghua Yan Jianxun Qi George F Gao 
the China National Grand S&T Spe-cial Project(No.2012ZX10001006);the National Natural Science Foundation of China(Grant No.31030030);GFG is a leading principal investigator of the NSFC Innovative Research Group(Grant No.81021003).
Leukocyte immunoglobulin-like receptors(LILRs),also called CD85s,ILTs,or LIRs,are important mediators of immune activation and tolerance that contain tandem immunoglobulin(Ig)-like folds.There are 11(in addition to tw...
关键词:LILRs D3D4 HLA binding crystal structure 
人CD96第一个IgV结构域的表达、结晶及晶体学分析
《生物工程学报》2013年第5期657-663,共7页姜文婧 张水军 严景华 郭宁 
国家自然科学基金(No.31030030)资助~~
CD96(Tactile)是一个主要表达在活化的T细胞、NK细胞上的免疫受体分子。它属于免疫球蛋白超家族,胞外区有3个免疫球蛋白结构域(V1,V2/C和C)。最近的研究表明,CD96的第一个IgV结构域(CD96V1)在细胞粘附和NK细胞介导的杀伤过程中起着重要...
关键词:CD96 第一IgV结构域 细胞粘附分子 蛋白纯化 结晶 
HLA-A*2402多肽复合物的两种构象——对Wolynes理论的补充被引量:1
《生物工程学报》2012年第11期1370-1377,共8页刘传省 施一 高福 
国家自然科学基金(No.31030030)资助~~
Wolynes曾经提出,蛋白质的折叠沿着能量降低的方向进行,当达到一个能量的局部最低点,蛋白质就达到了一个相对稳定的状态。有些能量的局部最低点并非生物所需要,这样的能量最低点就成了能量陷阱。Wolynes的能量通道理论和自然选择学说很...
关键词:蛋白折叠 能量陷阱 构象 自然选择 
A strategy to produce monoclonal antibodies against gp96 by prime-boost regimen using endogenous protein and E.coli heterologously-expressed fragment被引量:1
《Journal of Central South University》2011年第6期1857-1864,共8页张誉丹 操胜 孟颂东 高福 
Project(31030030) supported by the National Natural Science Foundation of China
Gp96, a member of HSP90 family, is a versatile molecular chaperone with various newly-discovered functions, for example to serve as a low affinity, high capacity calcium binding protein, a natural adjuvant for therape...
关键词:monoclonal antibody priming-boost GP96 low immunogenic protein 
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