We are grateful to Dr W Bian and her team in Cell Biology Core facility of SIBCB for their excellent support in flow cytometry analysis and cell sorting, and Drs L Lin, Y Xia and H Xiao of National Center for Microarrays for their help in microarray analysis. We are particularly grateful to Dr Hsueh-Chi Yen at Institute of Mol Biol, Academia Sinica, and Dr Ivan Dikic of Goethe University for advice, and Drs Dangsheng Li, Lijian Hui and Jiarui Wu of SIBCB, and Dr Shirley Diamond of California Institute of Tech- nology for helpful discussion. We also thank Dr Ya-lan Wu and all other members of the Hu lab for support. This work was supported by the National Natural Science Foundation of China (31270828, 31070678, 81170491, 81072070 and 81470360), the 100 Talents award from CAS to RH and the Ministry of Science and Technology, China (2010CB912100, 2012CB910800 and 2013CB910900 to RH, and 2011CB915501 to KR). RH was also supported by a Sanofi-aventis SIBS Young Investigator award and funding from the Cancer Center of Xuhui Central Hospital (CCR2012003), Shanghai Institute of Neurosciences (SKLN-201206) and the Instrument Developing Project of the Chinese Academy of Sciences (YZ201339).
Global change in protein turnover (protein degradome) constitutes a central part of cellular responses to intrin- sic or extrinsic stimuli. However, profiling protein degradome remains technically challenging. Recen...