国家自然科学基金(30770662)

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相关期刊：《Cell Research》更多>>
相关主题：PSD-95S-PROTEINRESENSITIZATIONRECEPTOR-MEDIATEDDESENSITIZATION更多>>
相关领域：生物学农业科学更多>>
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PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation
《Cell Research》2009年第5期612-624,共13页Peihua Sun Jmgru Wang Welhua Gu Wei Cheng Guo-zhang Jin Eitan Friedman Jie Zheng Xuechu Zhen 
Acknowledgments We thank Dr Morgan Sheng （Harvard University, USA） for providing the cDNA construct for PSD-95. This study was sup- ported by the Natural Science Foundation of China （30770662, 30825042）; Hi-Tech Research and Development Program of China （2007AA02Z163）, National Basic Research Program （2009CB2200） to XZ, and funding from the National Institutes of Health （REY016754A） and the American Heart Association （0665201Y） to JZ. Part of this work was conducted in a facility constructed with support from Research Facilities Improvement Program Grant C06-RR-12088-01 from the National Center for Research Resources.
The present study aims to define the role of postsynaptic density （PSD）-95 in the regulation of dopamine （DA） receptor function. We found that PSD-95 physically associates with either D1 or D2 DA receptors in co-t...
关键词：PSD-95 dopamine receptor Gs-protein activation DESENSITIZATION recycling RESENSITIZATION 
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