RESENSITIZATION

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α-Pyrone Derivatives from a Streptomyces Strain Resensitize Tamoxifen Resistance in Breast Cancer Cells被引量：1
《Natural Products and Bioprospecting》2017年第4期329-334,共6页Rui-Min Yang Xiu-Lei Zhang Li Wang Jian-Ping Huang Jing Yang Yi-Jun Yan Jian-Ying Luo Xiang-Ting Wang Sheng-Xiong Huang 
the National Natural Science Foundation of China to S-X.H(No.81522044)and to X.W(No.31471226);High-end Science and Technology Talents Program of Yunnan Province to S-X.H(No.2013HA022);a Grant from the Thousand Youth Talents Program of China.
Tamoxifen resistance(TamR)is the underlying cause of treatment failure in many breast cancer patients receiving tamoxifen.In order to look for noncytotoxic natural products with the ability to reverse TamR,an extract ...
关键词：Breast cancer Tamoxifen resistance RESENSITIZATION a-Pyrone derivatives STREPTOMYCES 
PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation
《Cell Research》2009年第5期612-624,共13页Peihua Sun Jmgru Wang Welhua Gu Wei Cheng Guo-zhang Jin Eitan Friedman Jie Zheng Xuechu Zhen 
Acknowledgments We thank Dr Morgan Sheng （Harvard University, USA） for providing the cDNA construct for PSD-95. This study was sup- ported by the Natural Science Foundation of China （30770662, 30825042）; Hi-Tech Research and Development Program of China （2007AA02Z163）, National Basic Research Program （2009CB2200） to XZ, and funding from the National Institutes of Health （REY016754A） and the American Heart Association （0665201Y） to JZ. Part of this work was conducted in a facility constructed with support from Research Facilities Improvement Program Grant C06-RR-12088-01 from the National Center for Research Resources.
The present study aims to define the role of postsynaptic density （PSD）-95 in the regulation of dopamine （DA） receptor function. We found that PSD-95 physically associates with either D1 or D2 DA receptors in co-t...
关键词：PSD-95 dopamine receptor Gs-protein activation DESENSITIZATION recycling RESENSITIZATION 
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