国家自然科学基金(81171049)

作品数：8被引量：36H指数：4
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相关作者：陈军王燕杨艳杨帆李春丽更多>>
相关机构：首都医科大学空军军医大学第四军医大学第四军医大学唐都医院更多>>
相关期刊：《Neuroscience Bulletin》《空军军医大学学报》《生理学报》更多>>
相关主题：MELITTINPAINPOST-STROKEMAJORSPINAL更多>>
相关领域：医药卫生农业科学化学工程生物学更多>>
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Melittin, the Major Pain-Producing Substance of Bee Venom被引量：12
《Neuroscience Bulletin》2016年第3期265-272,共8页Jun Chen Su-Min Guan Wei Sun Han Fu 
supported by grants from the National Basic Research Development Program of China (2013CB 835100);the National Natural Science Foundation of China (81171049,31300919,and 31400948);the National Key Technology R&D Program,China (2013BAI04B04);the Twelfth Five-Year Project of China (AWS12J004)
Melittin is a basic 26-amino-acid polypeptide that constitutes 40-60% of dry honeybee（Apis mellifera）venom.Although much is known about its strong surface activity on lipid membranes,less is known about its painprod...
关键词：MELITTIN Algogen - Nociceptor Spinaldorsal horn PAIN 
Gabapentinoid Insensitivity after Repeated Administration is Associated with Down-Regulation of theα2δ-1 Subunit in Rats with Central Post-Stroke Pain Hypersensitivity被引量：3
《Neuroscience Bulletin》2016年第1期41-50,共10页Yan Yang Fei Yang Fan Yang Chun-Li Li Yan Wang Zhen Li Yun-Fei Lu Yao-Qing Yu Han Fu Ting He Wei Sun Rui-Rui Wang Jun Chen 
supported by the National Natural Science Foundation of China(81171049);the National Basic Research Development Program of China(2011CB504100 and2013CB835100);the National Key Technology R&D Program of China(2013BAI04B04);the Twelfth Five-Year Project of China(AWS12J004)
The α2δ-1 subunit of the voltage-gated Ca2＋ channel （VGCC） is a molecular target of gabapentin （GBP）, which has been used as a first-line drug for the relief of neuropathic pain. GBP exerts its anti-nociceptive...
关键词：Central post-stroke pain Calcium channel α2δ subunit Gabapentinoid Thalamic hemorrhagicstroke ~ Thalamus - Spinal dorsal horn 
Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin被引量：7
《Neuroscience Bulletin》2014年第6期887-902,共16页Fei Yang Han Fu Yun-Fei Lu Xiao-Liang Wang Yan Yang Fan Yang Yao-Qing Yu Wei Sun Jia-Shuang Wang Michael Costigan Jun Chen 
supported by grants from the National Natural Science Foundation of China (81171049);the National Basic Research Development Program of China (2011CB504100,2013CB835100 and 2013BAI04B04)
Intractable central post-stroke pain（CPSP） is one of the most common sequelae of stroke, but has been inadequately studied to date. In this study, we first determined the relationship between the lesion site and cha...
关键词：central post-stroke pain intracerebral hemorrhage intra-thalamic collagenase injection mechanical pain hypersensitivity gabapentinoids anti-allodynic effect 
Use of multi-electrode array recordings in studies of network synaptic plasticity in both time and space被引量：4
《Neuroscience Bulletin》2012年第4期409-422,共14页Ming-Gang Liu Xue-Feng Chen Ting He Zhen Li Jun Chen 
supported by grants from the National Natural Science Foundation of China(30770668,81070899,81171049);973 program (2011CB504100) to J.C
Simultaneous multisite recording using multi-electrode arrays（MEAs） in cultured and acutely-dissociated brain slices and other tissues is an emerging technique in the field of network electrophysiology.Over the past...
关键词：multi-electrode arrays acute hippocampal slices spatial neural plasticity temporal neural plasticity network electrophysiology 
Effects of a non-selective TRPC channel blocker, SKF-96365, on melittin-induced spontaneous persistent nociception and inflammatory pain hypersensitivity被引量：5
《Neuroscience Bulletin》2012年第2期173-181,共9页Jing Ding Jia-RuiZhang Yan Wang Chun-Li Li Dan Lu Su-Min Guan Jun Chen 
supported by grants from the National Natural Science Foundation of China (30770668, 81070899, and 81171049)
Objective Melittin is the main peptide in bee venom and causes both persistent spontaneous nociception and pain hypersensitivity. Our recent studies indicated that both transient receptor potential （TRP） vanilloid r...
关键词：TRPC channels MELITTIN persistent spontaneous nociception primary thermal hyperalgesia primary mechanicalhyperalgesia 
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