国家自然科学基金(81271606)

作品数:7被引量:18H指数:3
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相关作者:高识马庆杰纪铁凤纪滨贾兵更多>>
相关机构:吉林大学中日联谊医院北京大学厦门大学更多>>
相关期刊:《中华核医学与分子影像杂志》《Nuclear Science and Techniques》更多>>
相关主题:SPECT显像SPECT^99TC^M发射型计算机更多>>
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^99Tc^m3P4-RGD2与^99Tc^m—MIBI SPECT显像诊断乳腺癌的对比研究被引量:4
《中华核医学与分子影像杂志》2016年第2期184-185,共2页马庆杰 陈滨 高识 纪铁凤 温强 宋研 朱雷 续哲莉 柳林 
国家自然科学基金(81271606)
乳腺癌是女性常见的恶性肿瘤,早期明确诊断及尽早行外科手术等治疗是降低死亡率的关键因素。^99Tc^mMIBI是一种亲脂性阳离子物质,已被有效地用于乳腺癌早期诊断并得到临床广泛认可。^99Tc^m3P4-RGD2是一种与整合素αvβ3具有特异性高...
关键词:乳腺癌早期诊断 显像诊断 ^99TC^M SPECT MIBI 整合素ΑVΒ3 恶性脑胶质瘤 RGD三肽 
99 Tcm-3P4-RGD2 SPECT显像在乳腺癌诊断中的应用价值被引量:2
《中华核医学与分子影像杂志》2015年第6期498-499,共2页柳林 宋研 高识 纪铁凤 张海山 纪滨 陈滨 贾兵 王凡 续哲莉 马庆杰 
国家自然科学基金(81271606)
乳腺癌是世界范围内常见的女性恶性肿瘤,早期明确诊断能显著降低乳腺癌的死亡率[1-3]。乳腺X线检查是乳腺癌的常规检查方法,但其鉴别良恶性的效果并不理想,假阴性率高达34%,常延误治疗[4]。此外,其对可触及肿瘤和不可触及肿...
关键词:SPECT显像 鉴别诊断 乳腺癌 应用 价值 女性恶性肿瘤 乳腺X线检查 常规检查方法 
^(131)I-chTNT-mediated radioimmunotherapy for non-uptaking ^(131)I pulmonary metastases from differentiated thyroid carcinoma
《Nuclear Science and Techniques》2013年第6期56-60,共5页GAO Shi JI Tiefeng WEN Qiang CHEN Bin MA Qingjie CHEN Zuowei LIU Lin 
Supported by the National Natural Science Foundation of China(NSFC)projects(No.81271606);the Research Fund of Science and Technology Department of Jilin Province(Nos.201015185 and 201201041);the Research Fund of Shenzhen Sci-tech Department of Guangdong Province(No.201102154)
In this paper,the safety and efficacy of 131I-labeled mouse/human chimeric monoclonal antibody(131I-chTNT)-mediated radioimmunotherapy are evaluated because the patients have non-uptaking 131I pulmonary metastases fro...
关键词:免疫治疗 甲状腺癌 吸收 分化 放射 介导  不良反应 
^(99m)Tc-3P_4 -RGD_2 radiotracers for SPECT/CT of esophageal tumor被引量:3
《Nuclear Science and Techniques》2013年第4期38-43,共6页GAO Shi MA Qingjie WEN Qiang JIA Bing LIU Zhaofei CHEN Zuowei ZHANG Haishan LI Dandan 
Supported by National Natural Science Foundation of China(NSFC)projects(No.81271606);Research Fund of Science and Technology Department of Jilin Province(No.201015185 and No.201201041);the Research Fund of Shenzhen Sci-tech Department of Guangdong Province(No.201102154)
In recent years,several RGD(Arg-Gly-Asp)-based radiotracers have already been successfully tested in human for the visualization of integrin αvβ3,demonstrating its feasibility in tumor diagnosis.In this paper,we eva...
关键词:放射性示踪剂 SPECT 食管肿瘤 计算机断层扫描 肿瘤诊断 平均年龄 恶性肿瘤 病理诊断 
A pilot study on ^(99m)Tc-3PRGD2 scintigraphy in diagnosis of brain glioma被引量:1
《Nuclear Science and Techniques》2013年第2期36-40,共5页GAO Shi MA Qingjie CUI Qu LIU Lin ZHOU Xueyan JIA Bing CHEN Zuowei ZHANG Haishan 
Supported by the National Natural Science Foundation of China projects(No.81271606);the Research Fund of Science and Technology Department of Jilin province(No.200705327,No.201015185,and No.201201041);the Research Fund of Shenzhen Sci-tech Department of Guangdong province (No.201102154)
The 99mTc-3PRGD2 targeted SPECT/CT scanning was of significance in detecting differentiated glioma.In this work,the diagnostic value of 99mTc-3PRGD2 scintigraphy in brain glioma was evaluated by the ten clinically ver...
关键词:脑胶质瘤 诊断价值 显像 SPECT 扫描检测 X射线成像 临床验证 静脉注射 
^99Tc^m-3P4-RGD2 SPECT显像对孤立性肺结节的诊断价值被引量:8
《中华核医学与分子影像杂志》2013年第1期24-28,共5页孙昱 王任婕 高识 纪铁凤 纪滨 贾兵 戚良晨 马庆杰 
国家自然科学基金(81271606);吉林省自然科学基金(201015185);吉林省科技发展计划(200705323)
目的评价新的环状二聚体RGD^99Tc^m3P±RGD:SPECT显像定性和半定量分析法对SPN的诊断价值。方法选取21例CT上有SPN的患者进行前瞻性研究,其中男13例,女8例,年龄37~77(58±11)岁,给予(939±118)MBq^99Tc^m3P±RGD2后进行SPECT...
关键词:肺肿瘤  精氨酸 甘氨酸一天冬氨酸 体层摄影术 发射型计算机 单光子 x线计算机 
Pharmacokinetics and radiation dosimetry of ^(99m)Tc-3PRGD_2 in healthy individuals:A pilot study被引量:6
《Nuclear Science and Techniques》2012年第6期349-354,共6页CHENG Guanghui GAO Shi JI Tiefeng MA Qingjie JIA Bing CHEN Zuowei WANG Qing 
Supported by the National Natural Science Foundation of China(NSFC) projects(no.81271606);the Research Fund of Science and Technology Department of Jilin Province(no.201015185 and no.201201041);the Research Fund of Shenzhen Sci-tech Department of Guangdong Province(no.201102154)
99mTc-3PRGD2 is a new SPECT radiotracer for several tumor imaging with high uptake where integrinαvβ3 is highly expressed.This pilot study was to assess the safety,biodistribution and radiation dosimetry of 9,mTc-3P...
关键词:安全试验 健康人 药代动力学 辐射剂量 高放射性 SPECT 可视化分析 投资回报率 
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