We acknowledge financial support from the National Natural Science Foundation of China (Nos.21234004,91027023,21221063,and 21004028) and the 111 project (No.B06009).
Glutathione peroxidase (GPx) is a vital antioxidant enzyme involved in the reduction of reactive oxygen species and protects cells from oxidative damage.Consequently enormous efforts have been devoted to developing ar...
financial support from the National Natural Science Foundation of China(91027023,21234004,21274051,21221063,21004028);the 111 project(B06009)
Enzymes are biomacromolecules responsible for the abundant chemical biotransformations that sustain life. Recently, biochemists have discovered that multiple conformations and numerous parallel paths are involved duri...
supported by the National Natural Science Foundation of China(91027023,20874036,20921003,and 21004028);the Natural Science Foundation for the Youth(21004028);the Natural Science Foundation of China for Outstanding Younger Scientist(20725415);the 111 pro-ject(B06009);the National Basic Research Program(2007CB808006)
The active center of human glutaredoxin(hGrx1)shares a common thioredoxin fold and specific affinity for substrate glutathione (GSH)with natural glutathione peroxidase(GPx).hGrx1 was redesigned to introduce the cataly...