国家自然科学基金(21004028)

作品数:4被引量:4H指数:1
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相关作者:罗全张春秋刘俊秋更多>>
相关机构:吉林大学更多>>
相关期刊:《高分子学报》《Chinese Journal of Chemistry》《Science China Chemistry》《Science Bulletin》更多>>
相关主题:MEANSUNDERSTANDINGSUPRAMOLECULAR蛋白质MIMICS更多>>
相关领域:理学环境科学与工程生物学更多>>
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A Photo-responsive Catalytic Vesicle with GPx Activity被引量:1
《Chinese Journal of Chemistry》2014年第1期37-43,共7页Ruiqing Xiao Lipeng Zhou Zeyuan Dong Yuzhou Gao Junqiu Liu 
We acknowledge financial support from the National Natural Science Foundation of China (Nos.21234004,91027023,21221063,and 21004028) and the 111 project (No.B06009).
Glutathione peroxidase (GPx) is a vital antioxidant enzyme involved in the reduction of reactive oxygen species and protects cells from oxidative damage.Consequently enormous efforts have been devoted to developing ar...
关键词:PHOTO-RESPONSIVE SELF-ASSEMBLY VESICLE GPx mimics 
Understanding enzyme catalysis by means of supramolecular artificial enzymes被引量:2
《Science China Chemistry》2013年第8期1067-1074,共8页DONG ZeYuan ZHU JunYan LUO Quan LIU JunQiu 
financial support from the National Natural Science Foundation of China(91027023,21234004,21274051,21221063,21004028);the 111 project(B06009)
Enzymes are biomacromolecules responsible for the abundant chemical biotransformations that sustain life. Recently, biochemists have discovered that multiple conformations and numerous parallel paths are involved duri...
关键词:artificial enzymes cooperative motions catalytic mechanism substrate recognition supramolecular chemistry 
Engineering human seleno-glutaredoxin containing consecutive rarecodons as an artificial glutathione peroxidase
《Chinese Science Bulletin》2012年第1期25-32,共8页ZHANG Wei LUO Quan WANG XiaoPing ZHANG DongMei MIAO Lu XU JiaYun LUO GuiMin SHEN JiaCong LIU JunQiu 
supported by the National Natural Science Foundation of China(91027023,20874036,20921003,and 21004028);the Natural Science Foundation for the Youth(21004028);the Natural Science Foundation of China for Outstanding Younger Scientist(20725415);the 111 pro-ject(B06009);the National Basic Research Program(2007CB808006)
The active center of human glutaredoxin(hGrx1)shares a common thioredoxin fold and specific affinity for substrate glutathione (GSH)with natural glutathione peroxidase(GPx).hGrx1 was redesigned to introduce the cataly...
关键词:谷胱甘肽过氧化酶 稀有密码子 氧工程  硫氧还蛋白 营养缺陷型 动力学机制 人造 
以蛋白质为基础模拟谷胱甘肽过氧化物酶被引量:1
《高分子学报》2011年第9期1020-1025,共6页张春秋 罗全 刘俊秋 
国家自然科学基金(基金号91027023,20874036,20921003和21004028);国家杰出青年基金(基金号20725415);国家基础研究发展计划(973计划,项目号2007CB808006)资助项目
硒元素作为一种生命体中必须的微量元素,与人类的健康和疾病息息相关.硒元素主要以硒代半胱氨酸的形式存在于至少25种硒蛋白中,执行着多种生物功能.在这20多种硒蛋白中,谷胱甘肽过氧化物酶(GPx)作为一种主要的抗氧化酶,能够有效地利用...
关键词: 硒代半胱氨酸 谷胱甘肽过氧化物酶 
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