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作品数：223被引量：492H指数：9
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相关机构：四川大学中国人民解放军中国环境科学研究院中国科学院生态环境研究中心更多>>
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An insect cell-derived extracellular vesicle-based gB vaccine elicits robust adaptive immune responses against Epstein-Barr virus
《Science China(Life Sciences)》2025年第3期734-745,共12页Qian Wu Kaiyun Chen Wenhui Xue Guosong Wang Yanbo Yang Shaowei Li Ningshao Xia Yixin Chen 
supported by the National Natural Science Foundation of China(82073756).
Epstein-Barr virus(EBV),the first identified human tumor virus,is implicated in various human malignancies,infectious mononucleosis,and more recently,multiple sclerosis.Prophylactic vaccines have the potential to effe...
关键词：Epstein-Barr virus glycoprotein gB extracellular vesicle humoral immune responses cellular immune responses 
Biphasic glucose-stimulated insulin secretion over decades:a journey from measurements and modeling to mechanistic insights
《Life Metabolism》2025年第1期5-15,共11页Xiaohong Peng Kai Wang Liangyi Chen 
the National Center for Protein Sciences at Peking University in Beijing,China;supported by the National Natural Science Foundation of China(81925022,T2288102,and 32227802);the National Key Research and Development Program of China(2022YFC3400600);the Beijing Natural Science Foundation(Z20J00059 and 7244366);the Fundamental Research Funds for the Central Universities(PKU2024XGK011);supported by the New Cornerstone Science Foundation;the High-performance Computing Platform of Peking University.
Glucose-stimulated insulin release from pancreaticβ-cells is critical for maintaining blood glucose homeostasis.An abrupt increase in blood glucose concentration evokes a rapid and transient rise in insulin secretion...
关键词：glucose-stimulated insulin secretion vesicle pools readily releasableβ-cells β-cell heterogeneity 
Seasonal influence on miRNA expression dynamics of extracellular vesicles in equine follicular fluid
《Journal of Animal Science and Biotechnology》2025年第1期136-152,共17页Jean M.Feugang Ahmed Gad Nico G.Menjivar Ghassan M.Ishak Samuel Gebremedhn Melba O.Gastal Notsile H.Dlamini Radek Prochazka Eduardo L.Gastal Dawit Tesfaye 
Southern Illinois University,Carbondale,IL;Ministry of Higher Education&Scientific Research,Baghdad,Iraq;NIFA-USDA Hatch project accession#1016077(Multistate#W4171);USDAARS project 6066-31000-015-00D;NIH MS-IDeA network of Biomedical Research Excellence award 5P20GMI03476-19.GMI received a PhD scholarship from the Ministry of Higher Education&Scientific Research,Baghdad,Iraq.
Background Ovarian follicular fluid(FF)is a dynamic environment that changes with the seasons,affecting follicle development,ovulation,and oocyte quality.Cells in the follicles release tiny particles called extracellu...
关键词：Extracellular vesicle Follicle growth Follicular fluid HORSE MARE OVULATION Pre-ovulation Seasonal breeding 
Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism
《Neural Regeneration Research》2025年第1期93-106,共14页Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao Mei Tian Jian Wang Fengtao Liu Chuantao Zuo 
supported by the Research Project of the Shanghai Health Commission,No.2020YJZX0111(to CZ);the National Natural Science Foundation of China,Nos.82021002(to CZ),82272039(to CZ),82171252(to FL);a grant from the National Health Commission of People’s Republic of China(PRC),No.Pro20211231084249000238(to JW);Medical Innovation Research Project of Shanghai Science and Technology Commission,No.21Y11903300(to JG).
Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of parkinsonism....
关键词：aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease PARKINSONISM positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2 
Considerations regarding the application of Chinese herbal medicine-derived extracellular vesicle-like particles in a drug delivery system
《Acupuncture and Herbal Medicine》2024年第4期423-426,共4页Fucai Chen Yingjie Zhang Yu Zheng Longxiang Pan Jiale Li Liuqing Di Peng Cao Ruoning Wang 
supported by National Natural Science Foundation of China(82125037,82274104,82074024,82374042);Jiangsu Provincial Medical Innovation Center(CXZX202225);Natural Science Foundation Youth Project of Nanjing University of Chinese Medicine(NZY81903557);the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine(2020YLXK019);Young Elite Scientists Sponsorship Program by CACM(2021-QNRC2-A01).
“Chinese herbal medicine extracellular vesicles-like particles”(CHM-EVLPs)refer to vesicle-like nanoparticles secreted by Chinese herbal medicines.These particles possess a lipid bilayer framework and contain variou...
关键词：HERBAL application utilizing 
Targeting the LMP1-ALIX axis in EBV^(+)nasopharyngeal carcinoma inhibits immunosuppressive small extracellular vesicle secretion and boosts anti-tumor immunity
《Cancer Communications》2024年第12期1391-1413,共23页Fajian He Yan Gong Gan Tao Jianguo Zhang Qiuji Wu Yushuang Tan Yajie Cheng Chunsheng Wang Jinru Yang Linzhi Han Zhihao Wang Yanping Gao Jingyi He Rui Bai Peikai Sun Xiaoyan Yu Yajuan Zhou Conghua Xie 
Health Commission of Hubei Province Medical Leading Talent Project,and Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University,Grant/Award Numbers:ZNJC201922,ZNJC202007;Key Research&Development Project of Hubei Province,Grant/Award Number:2020BCA069;National Natural Science Foundation of China,Grant/Award Numbers:81803065,81972852;Research Projects of Biomedical Center of Hubei Cancer Hospital,Grant/Award Number:2022SWZX12。
Background:Immunotherapy has revolutionized the therapeutical regimen for nasopharyngeal carcinoma(NPC),yet its response rate remains insufficient.Programmed death-ligand 1(PD-L1)on small extracellular vesicles(sEVs)m...
关键词：Epstein-Barr virus latent membrane protein 1 small extracellular vesicle PD-L1 ALIX nasopharyngeal carcinoma 
Hypoxia combined with radiation reverses migration and invasion of head and neck squamous cell carcinoma by remodeling extracellular vesicle-mediated transfer of miR-23b-5p from cancer-associated fibroblasts
《Malignancy Spectrum》2024年第4期275-289,共15页Chuanshi He Mingzhe Xie Zhimi Zhang Bangrong Cao Huaichao Luo Guiquan Zhu Shun Lu Ling Li 
supported by the National Natural Science Foundation of China(81972541,81872196,and 82273307);the Natural Science Foundation of Sichuan Province(2022NSFSC0681 and 2022NSFSC0632)。
Background:Cancer-associated fibroblasts(CAFs),the main matrix components in the tumor microenvironment(TME),play a crucial role in tumor progression.Extracellular vesicles(EVs)as main mediators in intercellular commu...
关键词：cancer-associated fibroblast extracellular vesicle HYPOXIA RADIOTHERAPY head and neck squamous cell carcinoma 
Extracellular vesicles for delivering therapeutic agents in ischemia/reperfusion injury
《Asian Journal of Pharmaceutical Sciences》2024年第6期1-20,共20页Weihang Zhou Xinchi Jiang Jianqing Gao 
This work was supported by the National Natural Science Foundation of China(U22A20383,82003668);the Natural Science Foundation of Zhejiang Province(LD22H300002,LQ21H300002);Ningbo Technology Innovation 2025 Major Special Project(2022Z150).
Ischemia/reperfusion(I/R)injury ismarked by the restriction and subsequent restoration of blood supply to an organ.This process can exacerbate the initial tissue damage,leading to further disorders,disability,and even...
关键词：Extracellular vesicles Extracellular vesicle engineering Ischemia/reperfusion injury NANOCARRIER Drug delivery 
Extracellular vesicle-functionalized bioactive scaffolds for bone regeneration
《Asian Journal of Pharmaceutical Sciences》2024年第5期88-103,共16页Taozhao Yu Irene Shuping Zhao Hongguang Pan Jianhua Yang Huanan Wang Yongqiang Deng Yang Zhang 
This work was supported by the National Natural Science Foundation of China(No.31900966&82001105);the Guangdong Provincial Basic and Applied Basic Research(No.2019A1515110415);Shenzhen Medical Academy of Research and Translation(A2303069);the Shenzhen Basic Research Program General Project(JCYJ20220530162206012);Medicine Plus Project of Shenzhen University.
The clinical need for effective bone regeneration in compromised conditions continues to drive demand for innovative solutions.Among emerging strategies,extracellular vesicles(EVs)have shown promise as an acellular ap...
关键词：Extracellular vesicles EXOSOMES BIOMATERIALS Local delivery Bone regeneration 
Lipocoacervate,a tunable vesicle for protein delivery
《Nano Research》2024年第10期9135-9140,共6页Chia-Wei Yeh Nathaniel Wright Chelsea Loh Nabeen Chu Yadong Wang 
Controlled delivery of proteins and other biologics is a growing medium of therapy for diseases previously untreatable.Here we report a self-assembling,tunable vesicle for the controlled delivery of growth factors and...
关键词：complex coacervate drug delivery protein delivery HEPARIN lipid particle 
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