This work was supported by a grant from the National Natural Science Foundation of China (No. 30672193).Acknowledgements: We are grateful to the patients and their families for the cooperation, to the members of the Paediatric Heart Centre for support and staff of the Central Laboratory of Molecular Biology for the technical assistance. We specially thank Dr. ZHU Xiao-quan for the excellent advice and assistance and Dr. ZHANG Wei-min for helpful patient information.
Background The basic helix-loop-helix transcription factor HAND2 plays an essential role in cardiac morphogenesis. However, the prevalence of HAND2 mutations in congenial heart disease (CHD) and the correlation betw...
This study was supported by the grants from the National Natural Science Foundation of China (No.30672193) and the National Science Foundation of Beijing (No. Y0204004040231).The authors are grateful to the subjects for participating in this study. We also thank Dr. BU Ding-fang and Dr. ZHANG Hua for theh technical assistance.
Background Congenital heart disease (CHD) is the most common developmental anomaly in newborns. The germline mutations in GATA4 and NKX2.5 genes have been identified as responsible for CHD. The frequency of GATA4 an...