国家教育部博士点基金(20101202110005)

作品数:7被引量:22H指数:3
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相关作者:吴艳娜刘艳霞宋君秋尚曼张琦更多>>
相关机构:天津医科大学东丽医院天津市天和医院更多>>
相关期刊:《中国药理学通报》《天津医药》《中国应用生理学杂志》更多>>
相关主题:MICROVESICLES再灌注循环血微囊THORACIC更多>>
相关领域:生物学医药卫生轻工技术与工程农业科学更多>>
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Iptakalim ameliorates relaxation to acetylcholine in thoracic aortic rings impaired by microvesicles derived from hypoxia/reoxygenation-treated HUVECs被引量:3
《中国应用生理学杂志》2016年第6期481-486,共6页Kun-wei ZHANG Shao-xun WANG Ye-yi LI Su WEI Man SHANG Chao LIU Miao LIU Yi-lu WANG Qian ZHU Yan-na WU Jun-qiu SONG Yan-xia LIU 
supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China (20101202110005);the Natural Science Foundation of Tianjin (11JCZDJC18300);the Research Foundation of Tianjin Municipal Education Commission (20110106)
Objective: To investigate the effect of Iptakalim(Ipt) preventing injury of endothelial microvesicles(EMVs) derived from hypoxia/reoxygenation(H/R)-treated HUVECs on the relaxation of rat thoracic aortic rings and exp...
关键词:人脐静脉内皮细胞 主动脉 丝氨酸/苏氨酸激酶 复氧 缺氧 微泡 一氧化氮合酶 透射电子显微镜 
心肌缺血预适应循环血中微囊泡对大鼠心肌I/R损伤的作用被引量:8
《中国应用生理学杂志》2016年第2期97-101,共5页王艺璐 刘淼 尚曼 王瑶 张琦 王少勋 韦苏 张琨玮 刘超 吴艳娜 宋君秋 刘艳霞 
天津市自然科学基金项目(11JCZDJC18300);高校博士学科点专项科研基金项目(20101202110005);天津市高等学校科技发展基金计划项目(20110106)
目的:研究心肌缺血预适应(IPC)大鼠循环血中微囊泡(MVs)对大鼠在体心肌缺血/再灌注(I/R)损伤的作用及相关机制。方法:反复短暂结扎/松开大鼠冠状动脉左前降支建立大鼠IPC模型,自腹主动脉取血,超速离心法分离循环血中的IPC-MVs,并对其进...
关键词:细胞微囊泡 心肌缺血预适应 心肌缺血/再灌注 大鼠 细胞凋亡 
Flow cytometric analysis of circulating microvesicles derived from myocardial ischemic preconditioning and cardioprotection of ischemia/reperfusion injury in rats被引量:3
《中国应用生理学杂志》2015年第6期524-531,共8页Miao LIU Yi-lu WANG Man SHANG Yao WANG Qi ZHANG Shao-xun WANG Su WEI Kun-wei ZHANG Chao LIU Yan-na WU Ming-lin LIU Jun-qiu SONG Yan-xia LIU 
supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China(20101202110005);the Natural Science Foundation of Tianjin(11JCZDJC18300);the Research Foundation of Tianjin Municipal Education Commission(20110106)
Objective: To establish a flow cytometric method to detect the alteration of phenotypes and concentration of circulating microvesicles(MVs) from myocardial ischemic preconditioning(IPC) treated rats(IPC-MVs), and to i...
关键词:缺血/再灌注损伤 流式细胞仪分析 心肌梗死 缺血预处理 保护作用 大鼠 循环 微泡 
Microvesicles derived from hypoxia/reoxYgenation-treated human umbilical vein endothellal cells impair relaxation of rat thoracic aortic rings被引量:4
《中国应用生理学杂志》2014年第6期560-566,共7页Shao-xun WANG Qi ZHANG Man SHANG Su WEI Miao LIU Yi-lu WANG Meng-xiao ZHANG Yan-na WU Ming-lin LIU Jun-qiu SONG Yan-xia LIU 
supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China(20101202110005);the Natural Science Foundation of Tianjin(11JCZDJC18300);the Research Foundation of Tianjin Municipal Education Commission(20110106);the National Key Basic Research Program of China(973 Program, 2011CB933100)
Objective To investigate the effects of microvesicles(MVs) derived from hypoxia/reoxygenation(H/R)-treated human umbilical vein endothelial cells(HUVECs) on endothelium-dependent relaxation of rat thoracic aortic ring...
关键词:人脐静脉内皮细胞 主动脉 大鼠 细胞来源 微泡 复氧 缺氧 浓度依赖性 
大鼠循环血中血小板和内皮细胞来源微囊泡的检测
《天津医药》2014年第4期325-328,I0004,共5页张梦晓 尚曼 张琦 王瑶 吴艳娜 宋君秋 刘艳霞 
天津市自然科学基金项目(项目编号:11JCZDJC18300);高校博士学科点专项科研基金项目(项目编号:20101202110005);天津市高等学校科技发展基金计划项目(项目编号:20110106)
目的建立流式细胞术对大鼠循环血中细胞微囊泡(MVs)的检测方法,并测定心肌缺血预适应(IPC)处理大鼠循环血中血小板来源的MVs(PMVs)及内皮细胞来源的MVs(EMVs)。方法大鼠经腹主动脉取血,枸橼酸钠抗凝,室温下经两步离心获得无血小板血浆(P...
关键词:血小板 内皮细胞 流式细胞术 细胞微囊泡 缺血预适应 
Effects of endothelial microvesicles induced by A23187 on H9c2 cardiomyocytes被引量:2
《中国应用生理学杂志》2013年第6期559-564,共6页Man SHANG Qi ZHANG Meng-xiao ZHANG Yao WANG Yan CHEN Yan-na WU Jun-qiuSONG Ming-lin LIU Yan-xia LIU 
supported by the Specialized Research Fund for the Doctoral Program of Higher Education of China(20101202110005);the Natural Science Foundation of Tianjin(11JCZDJC18300);the Research Foundation of Tianjin Municipal Education Commission(20110106);the National Key Basic Research Program of China(973 Program,2011CB933100)
Objective To investigate the effects of endothelial microvesicles(EMVs) induced by calcium ionophore A23187 on H9c2 cardiomyocytes. Methods Human umbilical vein endothelial cells(HUVECs) were treated with 10 μmol/L A...
关键词:人脐静脉内皮细胞 心肌细胞凋亡 诱导 微泡 流式细胞术检测 钙离子载体 膜联蛋白V 荧光染色 
牛磺酸增强渐增再灌注心肌保护作用的实验研究被引量:5
《中国药理学通报》2012年第6期810-814,共5页鞠浩爽 尚跃丰 罗鹏 汪月光 张森 郭媛丽 吴艳娜 康毅 刘艳霞 
天津市应用基础及前沿技术研究计划(No11JCZDJC18300);高校博士学科点专项科研基金(No20101202110005)
目的研究牛磺酸对渐增再灌注处理的离体大鼠缺血/再灌注损伤心肌的保护作用。方法采用Langendorff离体心脏灌流法制备离体大鼠心肌缺血/再灌注模型。SD大鼠随机分为7组:正常对照组(Nor)、缺血/再灌注组(I/R)、渐增再灌注组(GR)、牛磺酸...
关键词:缺血/再灌注损伤 渐增再灌注 牛磺酸 心肌保护 凋亡 CASPASE-3 
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