国家自然科学基金(21174110)

作品数：4被引量：9H指数：2
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相关作者：马明李峰更多>>
相关机构：川渝中烟工业有限责任公司武汉大学更多>>
相关期刊：《Regenerative Biomaterials》《Science China Chemistry》《武汉大学学报（理学版）》更多>>
相关主题：MODULETEMPLATETRANSMEMBRANELOW-MOLECULAR-WEIGHTASSEMBLY更多>>
相关领域：理学医药卫生化学工程更多>>
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Polymeric prodrug for bio-controllable gene and drug co-delivery被引量：2
《Science China Chemistry》2016年第11期1397-1404,共8页Huizhen Jia Si Chen Renxi Zhuo Jun Feng Xianzheng Zhang 
supported by the National Natural Science Foundation of China (21374085, 21174110, 51233003);the Natural Science Foundation of Hubei Province of China (2014CFB697);the Fundamental Research Funds for the Central Universities (2042014kf0193)
A polymeric polyethylenimine(PEI)-based prodrug of anticancer doxorubicin(DOX)(PEI-hyd-DOX) was designed by attaching DOX to PEI via an acid-labile hydrazone bond, for the achievement of biocontrollable gene and drug ...
关键词：gene/drug co-delivery hydrazone bond p H-sensitivity polymeric prodrug transfection efficiency 
Template-module assembly to prepare low-molecular-weight gene transport system with enhanced transmembrane capability被引量：4
《Science China Chemistry》2014年第4期558-567,共10页YANG Bin LV Yin WANG QingRong LIU Yun AN Hong FENG Jun ZHANG XianZheng ZHUO RenXi 
supported by the National Basic Research Program of China(2011CB606202);the National Natural Science Foundation of China(21174110);the Ministry of Education of China(20120141130003);the Fundamental Research Funds for the Central Universities(2012203020210)
Based on specific host-guest interactions between amine-modified [3-cyclodextrin （CD-TAEA） and functional adamantane （AD） derivatives, a module-template strategy has been proposed for the construction of low-molec...
关键词：template-module assembly host-guest interaction gene delivery 
Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release被引量：3
《Regenerative Biomaterials》2014年第1期27-35,共9页Teng-Teng Cai Qi Lei Bin Yang Hui-Zhen Jia Hong Cheng Li-Han Liu Xuan Zeng Jun Feng Ren-Xi Zhuo Xian-Zheng Zhang 
This work was supported by the National Key Basic Research Program of China(2011CB606202);National Natural Science Foundation of China(Grant Nos.21374085,21174110 and 51303137);the Fundamental Research Funds for the Central Universities(2042014kf0193).
A novel Uralic(U)-rich linear-hyperbranched mono-methoxy poly(ethylene glycol)-hyperbranched polyglycerol-graft-Uralic(mPEG-HPG-g-U)nanoparticle(NP)was prepared as drug carrier for antitumor methotrexate(MTX).Due to t...
关键词：nucleobase Uralic H-bond interaction linear-hyperbranched copolymer drug loading efficiency PH-SENSITIVITY 
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