国家自然科学基金(30770901)

作品数:7被引量:5H指数:1
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相关作者:李泱兰云峰陈瑞杨洁赵旭燕更多>>
相关机构:中国人民解放军总医院更多>>
相关期刊:《心脏杂志》《Acta Pharmacologica Sinica》《Chinese Medical Journal》《中华老年多器官疾病杂志》更多>>
相关主题:HERGANTP75NTRMYOCARDIAL_INFARCTION瞬时外向钾电流更多>>
相关领域:生物学医药卫生农业科学理学更多>>
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AIIocryptopine and benzyltetrahydropalmatine block hERG potassium channels expressed in HEK293 cells被引量:5
《Acta Pharmacologica Sinica》2013年第6期847-858,共12页Kun LIN Yu-qi LIU Bin XU Jin-liao GAO Yi-cheng FU Yu CHEN Qiao XUE Li YANG 
This study was supported by grants from the National Natural Science Foundation of China (No 81170177, No 30770901). The authors would like to thank Prof Silvia G PRIORI from Molecular Cardiology, Fondazione Salvatore Maugeri IRCCS, at the University of Pavia in Italy for generously providing the hERG plasmid.
Aim: AIIocryptopine (ALL) is an alkaloid extracted from Corydalis decumbens (Thunb) Pers. Papaveraceae, whereas benzyltetrahydropalmatine (BTHP) is a derivative of tetrahydropalmatine extracted from Corydalis a...
关键词:allocryptopine benzyltetrahydropalmatine hERG current whole-cell patch-clamp recording anti-arrhythmic agent 
不同年龄大鼠心肌细胞瞬时外向钾电流的变化
《生理学报》2013年第2期185-192,共8页傅义程 陈瑞 陈美烟 陈钰 汪艳丽 徐斌 杨洁 尹彤 李泱 
supported by the National Natural Science Foundation of China(No.30770901)
本文旨在研究心肌细胞瞬时外向钾电流(transient outward potassium current,Ito)的随龄变化及其药物反应性改变。Sprague Dawley大鼠28只,分为青年组(3~5月龄)、成年组(13~15月龄)和老年组(22~24月龄)。酶法分离心室肌细...
关键词:大鼠 心室肌细胞 瞬时外向钾电流 心律失常 膜片钳技术 
Frequency- and state-dependent blockade of human ether-a-go-go-related gene K^+ channel by arecoline hydrobromide
《Chinese Medical Journal》2012年第6期1068-1075,共8页ZHAO Xu-yan LIU Yu-qi FU Yi-cheng XU Bin GAO Jin-liao ZHENG Xiao-qin LIN Min CHEN Mei-yan LI Yang 
This study was supported by the grants from the National Natural Science Foundation of China (No. 81170177 and No. 30770901 ).Acknowledgment: We would like to thank Prof. Priori, University of Pavia in Italy for generously providing the hERG plasmid.
Background The rapidly activating delayed rectifier potassium current (/Kr), whose pore-forming alpha subunit is encoded by the human ether-a-go-go-related gene (hERG), is a key contributor to the third phase of a...
关键词:arecoline hydrobromide hERG current anti-arrhythmic agent frequency-dependent manner state-dependent manner 
p75神经营养因子受体在心血管系统中的作用
《中华老年多器官疾病杂志》2011年第3期286-288,共3页蓝云锋 李泱 
国家自然基金(30770901)~~
p75神经营养因子受体属于神经营养因子的受体之一。越来越多的研究表明,p75NTR在心血管系统自主神经中发挥重要的作用,不仅促进交感神经的生长发育,还调节心脏神经递质的释放。p75NTR还抑制新生血管形成,具有一定的抗血管生成作用,且介...
关键词:P75NTR 交感神经 动脉粥样硬化 心室重构 
Effects of nerve growth factor on delayed afterdepolarization and triggered activity in the infarcted ventricle of rabbit model
《Journal of Medical Colleges of PLA(China)》2011年第1期13-20,共8页Gao Yuling Liu Yuqi Lan Yunfeng Wen Yi Fang Zhou Gao Jinliao Wang Xueping Wang Hongjuan Li Yang 
Supported by the General Program of National Natural Science of China(30770901)
The noninfarcted myocardium underwent significant electrophysiological remodelling as part of the healed myocardial infarction remodelling. This study aimed at investigating the effects of nervous growth factor (NGF...
关键词:Nervous growth factor Healed myocardial infarction Delayed afterdepolarization Triggered activity Ion channels 
p75NTR对兔心肌梗死模型跨室壁瞬时外向钾电流异质性的作用
《心脏杂志》2010年第5期641-646,共6页林琨 赵旭燕 文毅 兰云峰 刘谟焓 李泱 
国家自然科学基金项目资助(30770901)
目的:通过干预神经营养因子p75受体(p75NTR)探讨心肌梗死(MI)后神经过度增生对心肌细胞Ito,f异质性的影响。方法:选日本大耳兔40只随机分为陈旧性心梗(HMI)组、p75 NTR激活组、p75 NTR抑制组和假手术组,每组10只(n=10)。采用酶解法制备...
关键词:P75NTR 陈旧性心肌梗死 瞬时外向钾电流 跨室壁异质性 
Ion mechanism of isoproterenol on delayed afterdepolarization and triggered activity in the infarcted ventricle
《Journal of Geriatric Cardiology》2010年第3期180-183,共4页Jin-Liao Gao Hong-Juan Wang Yun-Feng Lan Zhou Fang Yan Liu Min Lin Yi-Cheng Fu Yang Li 
This work was supported by the National Natural Science Foundation of China (No: 30770901).
Objectives This study aimed at investigating the cellular mechanism of isoproterenol (ISO) on delayed afterdepolarizations (DADs) and triggered activity (TA) of the noninfarcted myocardium in the myocardial infa...
关键词:ISOPROTERENOL healed myocardial infarction delayed afterdepolarization triggered activity ion channels 
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