supported by grants from the National Science and Technology Major Project for Infectious Diseases of China(No.2012ZX10004503);the National Natural Science Foundation of China(No.81101248,No.81261120397 and No.81371828);the Deutsche Forschungs-gemeinschaft(Transregio TRR60)
Cytosolic retinoic acid-inducible gene I(RIG-I) is an important innate immune RNA sensor and can induce antiviral cytokines, e.g., interferon-β(IFN-β). Innate immune response to hepatitis B virus(HBV) plays a ...
the Deutsche Forschungsgemeinschaft(TRR60 and GK 1045/2);National Major Science and Technology Project for Infectious Diseases of China(2008ZX10002-011,2012ZX10004503);the National Natural Science Foundation of China(No.30271170,30571646,81101248);the International Science&Technology CooperationProgram of China(2011DFA31030)for supporting some of the work in the review
Chronic hepatitis B virus(CHB) is currently treated with either interferon-based or nucleot(s)idebased antiviral therapies.However,treatment with pegylated interferon alpha results in a durable antiviral response in o...