国家自然科学基金(81101248)

作品数:3被引量:11H指数:2
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相关作者:冯雪梅王俊忠黄顺梅王宝菊朱彬更多>>
相关机构:华中科技大学华中科技大学同济医学院附属同济医院更多>>
相关期刊:《Virologica Sinica》《中华肝脏病杂志》更多>>
相关主题:HEPATITIS_B_VIRUSTREATMENTSTRATEGIESNEWIMMUNOMODULATION更多>>
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Molecular Cloning,Characterization and Expression Analysis of Woodchuck Retinoic Acid-Inducible GeneⅠ
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2016年第3期335-343,共9页严琦 刘钦 李蒙蒙 李芳慧 朱彬 Jun-zhong WANG 王俊忠 卢银平 刘嘉 吴珺 郑昕 陆蒙吉 王宝菊 杨东亮 
supported by grants from the National Science and Technology Major Project for Infectious Diseases of China(No.2012ZX10004503);the National Natural Science Foundation of China(No.81101248,No.81261120397 and No.81371828);the Deutsche Forschungs-gemeinschaft(Transregio TRR60)
Cytosolic retinoic acid-inducible gene I(RIG-I) is an important innate immune RNA sensor and can induce antiviral cytokines, e.g., interferon-β(IFN-β). Innate immune response to hepatitis B virus(HBV) plays a ...
关键词:retinoic acid-inducible gene I woodchuck woodchuck hepatitis virus 
New therapeutic vaccination strategies for the treatment of chronic hepatitis B被引量:9
《Virologica Sinica》2014年第1期10-16,共7页Jia Liu Anna Kosinska Mengji Lu Michael Roggendorf 
the Deutsche Forschungsgemeinschaft(TRR60 and GK 1045/2);National Major Science and Technology Project for Infectious Diseases of China(2008ZX10002-011,2012ZX10004503);the National Natural Science Foundation of China(No.30271170,30571646,81101248);the International Science&Technology CooperationProgram of China(2011DFA31030)for supporting some of the work in the review
Chronic hepatitis B virus(CHB) is currently treated with either interferon-based or nucleot(s)idebased antiviral therapies.However,treatment with pegylated interferon alpha results in a durable antiviral response in o...
关键词:hepatitis B virus woodchuck hepatitis virus therapeutic vaccination IMMUNOMODULATION programmed death-1 
用大鼠模型评价齐多夫定及阿德福韦酯对线粒体的毒性损伤被引量:2
《中华肝脏病杂志》2012年第10期794-797,共4页朱彬 朱珍妮 王俊忠 黄顺梅 冯雪梅 李安意 杨东亮 王宝菊 
基金项目:国家科技重大专项(2008ZX10002-011);国家自然科学基金(81101248)
目的用大鼠模型评估齐多夫定(AZT)及阿德福韦酯(ADV)对线粒体的毒性损伤。方法SD大鼠随机分为AZT、ADV和空白对照三组,连续灌胃给药28d,检测大鼠肝、肾、骨骼肌、心肌线粒体的细胞色素c氧化酶活性、细胞色素b基因含量,及用电子...
关键词:线粒体 细胞色素C氧化酶 齐多夫定 阿德福韦酯 
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