国家自然科学基金(30801354)

作品数:5被引量:37H指数:4
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相关作者:孙莹赵雪俭张灵吴荒王波更多>>
相关机构:吉林大学第一医院吉林大学吉林大学第二医院更多>>
相关期刊:《Asian Journal of Andrology》《中国实验诊断学》《中国病理生理杂志》更多>>
相关主题:PROSTATE_CANCERSTAT3SURVIVINID-BASEDSUPPRESSES更多>>
相关领域:医药卫生生物学农业科学更多>>
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;~lasmid-based Survivin shRNA and GRIM-19 carried by attenuated Salmonella suppresses tumor cell growth被引量:7
《Asian Journal of Andrology》2012年第4期536-545,共10页Yan-Bo Liu Ling Zhang Ya-Xiong Guo Li-Fang Gao Xi-Chun Liu Li-Juan Zhao Bao-Feng Guo Li-Jing Zhao Xue-Jian Zhao De-Qi Xu 
This study was supported by the National Natural Science Foundation of China (No. 30801354 and No. 3097079J), Jilin Provincial Science and Technology Department (No. 20080154 and No.20110146) and the PhD Programs Foundation of Ministry of Education of China (No. 200801831077) (Ling Zhang)
Persistent activation of Survivin and its overexpression contribute to the formation, progression and metastasis of several different tumor types. Therefore, Survivin is an ideal target for RNA interference mediated-g...
关键词:GRIM-19 prostate cancer RNAi Salmonella enterica serovar typhimurium SURVIVIN tumor cell growth 
Is XMRV a causal virus for prostate cancer?
《Asian Journal of Andrology》2011年第5期698-701,共4页Zhen-Zhen Zhang Bao-Feng Guo Zhuang Feng Ling Zhang Xue-Jian Zhao 
ACKNOWLEDGMENTS This work was funded by the National Natural Science Foundation of China (No. 30801354 and No. 30970791) and Jilin Provincial Science and Technology Department, China (grant No. 20080154).
The potential association between xenotropic murine leukaemia virus-related gammaretrovirus (XMRV) and prostate cancer (PCa) has been documented since 2006, It is important for furthering our understanding of the ...
关键词:prostate cancer REVIEW XMRV 
Plasmid-based Stat3 siRNA delivered by hydroxyapatite nanoparticles suppresses mouse prostate tumour growth in vivo被引量:5
《Asian Journal of Andrology》2011年第3期481-486,514,共7页Zuo-Wen Liang Bao-Feng Guo Yang Li Xiao-Jie Li Xin Li Li-Jing Zhao Li-Fang Gao Hao Yu Xue-Jian Zhao Ling Zhang Bao-Xue Yang 
The authors would thank Mr Qiang-Lin Duan for English usage and paper revision.This work was funded by the National Natural Science Foundation of China (No. 30801354, No. 30970791 and No. 30870921), the Fundamental Research Funds for the Central Universities of China (No. 200810012) and the Jilin Provincial Science & Technology Department, China (No. 20080154).
DNA vector-based Stat3-specific RNA interference (si-Stat3) blocks Stat3 signalling and inhibits prostate tumour growth. However, the antitumour activity depends on the efficient delivery of si-Stat3. The effects on...
关键词:apoptosis HYDROXYAPATITE prostate cancer RNA interference Star3 
STAT3-siRNA对胃癌细胞株SGC-7901增殖与凋亡的影响被引量:11
《中国病理生理杂志》2010年第2期393-395,共3页孙莹 于浩 张灵 高丽芳 赵雪俭 
国际科技合作重点资助项目(No.2004DFB02000);国家自然科学基金资助项目(No.30801354)
目的:探讨siRNA沉默STAT3基因表达对胃癌细胞的生长抑制作用。方法:用已构建pGCsi-lencerH1/STAT3siRNA重组质粒,转染胃癌细胞SGC-7901,采用Western blotting、RT-PCR技术观察重组质粒对STAT3基因表达的影响;用MTT法观察重组质粒对胃癌...
关键词:胃肿瘤 RNA干扰 STAT3 细胞凋亡 
Stat3、Survivin和Bcl-2在胃癌组织中的表达被引量:14
《中国实验诊断学》2010年第1期73-75,共3页孙莹 吴荒 王波 张灵 赵雪俭 
国家自然科学基金项目(30801354);吉林省科学技术厅青年基金(20080154)
目的探讨Stat3、Survivin和Bcl-2在胃癌组织中的表达情况。方法对42例胃癌组织和19例正常胃组织采用免疫组织化学方法分析,采用Mann-Whitney U法分析组间差异。结果胃癌组中Stat3、Survivin和Bcl-2表达阳性的分别有31例、29例和25例,正...
关键词:胃癌 STAT3 SURVIVIN BCL-2 免疫组织化学 
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