supported by the grants from the National Natural Science Foundation of China(30370447);the Major State Basic Research Development Program of China(2005CB522702);the Science and Technology Commission of Shanghai Municipality(03DZ14019,03DZ14018,03DJ14088,05DZ22915);Special Funds for Major State Basic Research of China(2002CB713803)
Endostatin, a C-terminal fragment of collagen 18a, inhibits the growth of established tumors and metastases in vivo by inhibiting angiogenesis. However, the purification procedures required for largescale production a...