This work was supported by grants from the National Basic Research Program of China, the Ministry of Science and Technology, China (No_ 2005CB0523101), the National Natural Science Foundation of China (No_ 30440061 and 30572229), the Science and Technology Commission of Shanghai Municipality (No_ 06XD14030), and the Shanghai Municipal Health Bureau (No_ LJ06052).Acknowledgements We thank George A JACOBY and David C HOOPER for providing reference strains E coli J53Az^R, E coli V517, and E coli R27. We are also grateful to George A JACOBY for critically reviewing the manuscript.
Aim: To identify the location and the relationship, and to analyze the genetic background of 2 plasmid-mediated quinolone resistance genes, qnrB4 and qnrS1, carried by a clinical strain of Klebsiella pneumoniae (Kpn...