国家重点基础研究发展计划(2012AA02A706)

作品数：2被引量：13H指数：2
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相关期刊：《Science China(Life Sciences)》《Synthetic and Systems Biotechnology》更多>>
相关主题：GENETICACTINOPLANESSPBY-PRODUCTACARBOSE更多>>
相关领域：经济管理轻工技术与工程化学工程更多>>
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Improving acarbose production and eliminating the by-product component C with an efficient genetic manipulation system of Actinoplanes sp.SE50/110被引量：9
《Synthetic and Systems Biotechnology》2017年第4期302-309,共8页Qinqin Zhao Huixin Xie Yao Peng Xinran Wang Linquan Bai 
We are grateful to Prof.Yuhui Sun from Wuhan university,China,and the late Prof.Keqian Yang from Institute of Microbiology,Chinese Academy of Sciences,for providing plasmids pWHU2653 and pDR-4-K^*,respectively.This work was supported by grants from the National Natural Science Foundation of China(No.31470157,21661140002);the Ministry of Science and Technology of China(No.2012AA02A706).
Theα-glucosidase inhibitor acarbose is commercially produced by Actinoplanes sp.and used as a potent drug in the treatment of type-2 diabetes.In order to improve the yield of acarbose,an efficient genetic manipulatio...
关键词：Actinoplanes sp. ACARBOSE Genetic manipulation CONJUGATION Component C 
Asm8, a specific LAL-type activator of 3-amino-5-hydroxy-benzoate biosynthesis in ansamitocin production被引量：4
《Science China(Life Sciences)》2013年第7期601-608,1-3,共8页PAN WenQin KANG QianJin WANG Lei BAI LinQuan DENG ZiXin 
supported by grants from the Ministry of Science and Technology of China (2012CB721005, 2012AA02A706, 2011ZX08009-001, 2012AA022107);the National Natural Science Foundation of China (31070070, 31121064);Ministry of Education of China (20110073110048);the SJTU-UM Collaborative Program
The highly potent antitumor agent ansamitocin P3 is a macrolactam isolated from Actinosynnema pretiosum ATCC 31565. A 120-kb DNA fragment was previously identified as the ansamitocin biosynthetic gene cluster, and con...
关键词：ansamitocins regulation AHBA Actinosynnema pretiosum LuxR family 
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