This work was supported by National Key R&D Program of China(2020YFA0509400)(to Y.Y.);National Natural Science Foundation of China 81970196(to C.G.)and 82073885(to Y.Y.);Natural Science Foundation of Jiangsu Province BK20200097(to C.G.);Jiangsu Postgraduate Research and Practice Innovation Program KYCX20_1479(to X.T.)and KYCX21_1769(to R.W.).
Multiple myeloma(MM)is an incurable plasma cell malignancy in the bone marrow characterized by chromosome instability(CIN),which contributes to the acquisition of heterogeneity,along with MM progression,drug resistanc...