Supported by the Natural Science Foundation of Hubei Province of China(2014CFB696);the Opening Project of Key Laboratory of Biomedical Polymers of Ministry of Education at Wuhan University(20150102);the National Natural Science Foundation of China(21074098)
A novel camptothecin (CPT) prodrug was successfully synthesized by conjugating CPT to adamantanecarboxylic acid (AD) via a cleavable disulfide linkage. The resulting CPT-ss-AD prodrug could act as a low molecular ...