国家自然科学基金(31025010)

作品数:1被引量:3H指数:1
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相关期刊:《Cell Research》更多>>
相关主题:YPPHOSPHODIESTERASEPHOSPHODIESTERASESCHOLERAD-G更多>>
相关领域:生物学环境科学与工程更多>>
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Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP被引量:3
《Cell Research》2015年第5期539-550,共12页Juyi Gao Jianli Tao Weili Liang Meng Zhao Xiaoxia Du Shan Cui Haifeng Duan Biao Kan Xiaodong Su Zhengfan Jiang 
We thank Dr Yulong Li for critical discussion and Dr Zhijian J Chen for human cGAS expression vector and helpful technical assistance. This work was supported by the National Natural Science Foundation of China (31025010, 31230023, 81171640 and 91129000), and the Chinese Ministry of Science and Technology (2011CB911103 and 2014CB542600).
Cyclic dinucleotides act as intracellular second messengers, modulating a variety of cellular activities including innate immune activation. Although phosphodiesterases (PDEs) hydrolyzing c-di-GMP and c-di-AMP have ...
关键词:3'3'-cGAMP V. cholera PHOSPHODIESTERASE HD-GYP 
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