国家自然科学基金(U0832601)

作品数：7被引量：21H指数：4
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相关作者：况轶群汤霞郑永唐更多>>
相关机构：中国科学院中国科学院研究生院更多>>
相关期刊：《Cellular & Molecular Immunology》《病毒学报》《Science China(Life Sciences)》《Zoological Research》更多>>
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Association of TRIMCyp and TRIM5α from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition
《Science China(Life Sciences)》2018年第8期954-965,共12页Dan Mu Jia-Wu Zhu Feng-Liang Liu Hong-Yi Zheng Yong-Tang Zheng 
supported by grants from the National Natural Science Foundation of China (81471620, 81671627, 81571606, 81172876, U0832601);the 13th Five-Year Key Scientific and Technological Program of China (2017ZX10304402-002-004, 2017ZX10202102-001-005);the Knowledge Innovation Program of the Chinese Academy of Sciences (KJZD-EW-L1002, KSCX2-EW-R-13);the National Key Research & Development Plan (2016YFC1201000);the National Basic Research Program of China (2012CBA01305)
TRIM5α restricts retroviruses in a species-specific manner. Cyclophilin A was independently retrotransposed into the TRIM5 loci in different species, leading to the generation of antiviral TR1M5-cyclophilin A （TRIM...
关键词：TRIMCyp/TRIM5α assam macaque HIV-1 N-MLV functional trade-off 
Flow cytometric characterizations of leukocyte subpopulations in the peripheral blood of northern pig-tailed macaques （Macaca leonina）被引量：4
《Zoological Research》2014年第6期465-473,共9页Hong-Yi ZHENG Ming-Xu ZHANG Lin-Tao ZHANG Xiao-Liang ZHANG Wei PANG Long-Bao LYU Yong-Tang ZHENG 
This work was supported by the National Special Science Research Program of China （2012CBA01305）; the National Natural Science Foundation of China （81172876, U0832601, 81273251, U1202228）; the Knowledge Innovation Program of CAS （KSCX2-EW-R-13） and the National Science and Technology Major Project （2013ZX10001-002, 2012ZX10001-007）We thank Mr. Zhen-Fei Hu,Gui Li and Dong-Ti Huang of Kunming Primate Research Center for their assistance with the experiments.
Pig-tailed macaques(Macaca nemistrina group) have been extensively used as non-human primate animal models for various human diseases in recent years, notably for AIDS research due to their sensitivity to HIV-1. North...
关键词：Northern pig-tailed macaque Flow cytometry Leukocyte subpopulation Age Sex 
Replication potentials of HIV-1/HSIV in PBMCs from northern pigtailed macaque （Macaca leonina）被引量：5
《Zoological Research》2014年第3期186-195,共10页Ai-Hua LEI Gao-Hong ZHANG Ren-Rong TIAN Jia-Wu ZHU Hong-Yi ZHENG Wei PANG Yong-Tang ZHENG 
Foundation items： This work was supported by the National Basic Research Program （2012CBA01305）; the National Natural Science Foundation of China （81172876, U0832601, 81273251 and U 1202228） the Knowledge Innovation Program of CAS （KSCX2-EW-R-13, Y206A- 71181）, and the Key Scientific and Technological Program of China （2012ZX10001-007, 2013ZX10001-002）. Acknowledgements： We thank Prof. Guang-Xia GAO （Institute of Biophysics, Chinese Academy of Sciences） for kindly providing HSIV proviral plasmids.We also thank Long-Bao LV, Gui LI and Dong- Ti HUANG of Kunming Primate Research Center for their assistance in obtaining blood samples from northem pig-tailed macaques （M. leonina） and Chinese rhesus macaques.
The northern pig-tailed macaque （Macaca leonina） has been identified as an independent species of Old World monkey, and we previously found that PBMCs from M. leonina were susceptible to human immunodeficiency virus...
关键词：HIV-1 HSIV REPLICATION PBMC Northern pig-tailed macaque （Macaca leonina） 
Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques （Macaca leonina）被引量：8
《Zoological Research》2014年第3期196-203,共8页Xiao-Liang ZHANG Wei PANG De-Yao DENG Long-Bao LV Yue FENG Yong-Tang ZHENG 
Foundation items： This work was supported by the National Natural Science Foundation of China （81172876, U0832601, 81273251, U1202228）; the National Special Science Research Program of China （2012CBA01305）; the National Science and Technology Major Project （2013ZX10001-002, 2012ZX10001-007） and the Knowledge Innovation Program of CAS （KSCX2-EW-R-13）.
The northem pig-tailed macaque （NPM, Macaca leonina） has become a widely used animal model in biomedical research. In this study, we measured serum immunoglobulin IgG, IgM, IgA, complement C3, C4 and CRP levels in 3...
关键词：Northern pig-tailed macaque （Macaca leonina） IMMUNOGLOBULIN Complement C-reactive protein 
The Influence of Age and Sex on the Cell Counts of Peripheral Blood Leukocyte Subpopulations in Chinese Rhesus Macaques被引量：5
《Cellular & Molecular Immunology》2009年第6期433-440,共8页Hou-Jun Xia Gao-Hong Zhang Rui-Rui Wang Yong-Tang Zheng 
This work was supported in part by grants from Scientific and Technological Projects of China(2008ZX10001-002,2008ZX10001-015,2008ZX10005-005,2009ZX09501-029);Yunnan(2006PT08);973 Program(2006CB504208,2009CB522306);the NSFC(30471605,30671960,U0832601,30872317);CAS(KSCX1-YW-R-15,KSCX2-YW-R-185),and“Western Light”Projects.
Non-human primates such as Chinese rhesus macaques are the favorable models for preclinical study of potential therapeutic drugs,vaccines and mechanisms of human diseases.Little is known about the normal levels of leu...
关键词：Chinese rhesus macaque leukocyte subpopulation absolute count age SEX 
TRIM5α分子结构和限制HIV-1复制机制的研究进展被引量：6
《病毒学报》2009年第2期148-153,共6页汤霞 况轶群 郑永唐 
国家重点基础研究发展计划(973)(2006CB504302);国家自然科学基金(30671960,U0832601);中国科学院知识创新工程重要方向(KSCX1-YW-R-15)
关键词：TRIM5α CYPA HIV-1 灵长类动物 
Phenotype and Function of Monocyte-Derived Dendritic Cells from Chinese Rhesus Macaques被引量：1
《Cellular & Molecular Immunology》2009年第3期159-165,共7页Houjun Xia Hongliang Liu Gaohong Zhang Yongtang Zheng 
Dendritic cells （DCs） play a pivotal role in linking the innate immunity and acquired immunity in responses to pathogen. Non-human primates such as Chinese Rhesus Macaque （CRM） are the favorable models for preclin...
关键词：monocyte-derived dendritic cell animal model Chinese Rhesus Macaque 
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