supported by the Guangdong Natural Science Foundation(S2011010004264);Guangdong Science and Technology Program(No.2008B020100001);Open Fund of MOE Key Laboratory of Aquatic Product Safety,Foreign Expert Program at Sun Yat-sen University,Open Fund of Laboratory(201501024);2016 Key Project Budget at Sun Yat-sen University,The National Natural Science Foundation of China(21601209 and J1310025);The National Key Technology R&D Program(2012BAD17B03);The National Key Technology R&D Program(2011BAD13B10);the Public Welfare and Competence Program of Guangdong Province (2016B020204001)