supported by the grants from the General Program of National Natural Science Foundation of China(81172591);Anhui Provincial Natural Science Foundation(090413074);the Open Funds of the State Key Laboratory of Medical Molecular Biology(Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences)(2060204);Scientific Research of BSKY(XJ200801)from Anhui Medical University.
The adeno-associated virus (AAV) genome can be stably integrated into the AAVS1 region of human chromosome 19 (19q13.4-qter) with the assistance of Rep68/78 protein. In the current models of AAV integration in a l...