This work was supported by grants from the Ministry of Science and Technology of China (2014CB541903, 2012CB910404), the National Natural Science Foundation of China (31171348, 31371414), the Shanghai Municipal Education Commission (14zz042), the State Key Laboratory of Drug Research (SIMM1302KF-09) and the Fundamental Research Funds for the Central Universities.
Many G protein-coupled receptors (GPCRs) are reported to be involved in the pathogenesis of multiple sclerosis (MS), and -40% of all identified GPCRs rely on the Gaq/11 G protein family to stimulate inositol lipid...